Myasthenia gravis: epidemiology, pathophysiology and clinical manifestations

L Dresser, R Wlodarski, K Rezania… - Journal of clinical medicine, 2021 - mdpi.com
Myasthenia gravis (MG) is an autoimmune neurological disorder characterized by defective
transmission at the neuromuscular junction. The incidence of the disease is 4.1 to 30 cases …

The regulation of bone metabolism and disorders by Wnt signaling

K Maeda, Y Kobayashi, M Koide, S Uehara… - International journal of …, 2019 - mdpi.com
Wnt, a secreted glycoprotein, has an approximate molecular weight of 40 kDa, and it is a
cytokine involved in various biological phenomena including ontogeny, morphogenesis …

Safety, efficacy, and tolerability of efgartigimod in patients with generalised myasthenia gravis (ADAPT): a multicentre, randomised, placebo-controlled, phase 3 trial

JF Howard, V Bril, T Vu, C Karam, S Peric… - The Lancet …, 2021 - thelancet.com
Background There is an unmet need for treatment options for generalised myasthenia gravis
that are effective, targeted, well tolerated, and can be used in a broad population of patients …

Autoantibody specificities in myasthenia gravis; implications for improved diagnostics and therapeutics

K Lazaridis, SJ Tzartos - Frontiers in immunology, 2020 - frontiersin.org
Myasthenia gravis (MG) is an autoimmune disease characterized by muscle weakness and
fatiguability of skeletal muscles. It is an antibody-mediated disease, caused by …

Myasthenia gravis—autoantibody characteristics and their implications for therapy

NE Gilhus, GO Skeie, F Romi, K Lazaridis… - Nature reviews …, 2016 - nature.com
Myasthenia gravis (MG) is an autoimmune disorder caused by autoantibodies that target the
neuromuscular junction, leading to muscle weakness and fatigability. Currently available …

Seronegative autoimmune diseases: A challenging diagnosis

MV Lenti, CM Rossi, F Melazzini, M Gastaldi… - Autoimmunity …, 2022 - Elsevier
Autoimmune diseases (AID) are increasingly prevalent conditions which comprise more
than 100 distinct clinical entities that are responsible for a great disease burden worldwide …

Clinical features, pathogenesis, and treatment of myasthenia gravis: a supplement to the Guidelines of the German Neurological Society

N Melzer, T Ruck, P Fuhr, R Gold, R Hohlfeld… - Journal of …, 2016 - Springer
Myasthenia gravis (MG) is an autoimmune antibody-mediated disorder of neuromuscular
synaptic transmission. The clinical hallmark of MG consists of fluctuating fatigability and …

Advances in the understanding of disease mechanisms of autoimmune neuromuscular junction disorders

MG Huijbers, A Marx, JJ Plomp, R Le Panse… - The Lancet …, 2022 - thelancet.com
Muscle weakness and fatigue are the hallmarks of autoimmune neuromuscular junction
disorders. Although a plethora of immunosuppressive treatments exist, no cure is available …

Generalized myasthenia gravis: classification, clinical presentation, natural history, and epidemiology

MK Hehir, NJ Silvestri - Neurologic clinics, 2018 - neurologic.theclinics.com
Myasthenia gravis (MG) is the most common disorder of the neuromuscular junction. It is the
prototypic autoimmune disease most commonly caused by antibodies to the acetylcholine …

Myasthenia gravis: a comprehensive review of immune dysregulation and etiological mechanisms

S Berrih-Aknin, R Le Panse - Journal of autoimmunity, 2014 - Elsevier
Autoimmune myasthenia gravis (MG) is characterized by muscle weakness caused by
antibodies directed against proteins of the neuromuscular junction. The main antigenic …