Monocyte-derived macrophages can determine the outcome of the immune response and
whether this response contributes to tissue repair or mediates tissue destruction. In addition …

Macrophage accumulation has long been recognized as a feature of allograft rejection, yet
the role of macrophages in rejection remains underappreciated. Macrophages contribute to …

Ischemia/reperfusion injury (IRI) may activate innate immunity through the engagement of
TLRs by endogenous ligands. TLR4 expressed within the kidney is a potential mediator of …

IL-18 is a proinflammatory cytokine produced by macrophages and other cell types present
in the kidney during ischemia-reperfusion injury (IRI), but its role in this injury is unknown …

Multiple cell types infiltrate acutely rejecting renal allografts. Typically, monocytes and T cells
predominate. Although T cells are known to be required for acute rejection, the degree to …

Renal inflammation may result from a myriad of insults and often is characterized by the
presence of infiltrating inflammatory leukocytes within the glomerulus or tubulointerstitium …

Interleukin (IL)-18 is a relatively new pro-inflammatory cytokine, formerly known as interferon-
γ-inducing factor, which induces interferon-γ production in T cells and natural killer cells. It is …

Monocytes/macrophages (MO) have long been recognized to be involved in renal allograft
rejection. Monocytes/macrophages have been detected in the glomerular, vascular, and …

Interleukin (IL)-18 is produced by leukocytes and renal parenchymal cells (tubular epithelial
cells, podocytes, and mesangial cells). The IL-18 receptor (IL-18R) is expressed on these …

Pancreatic islets contain cells that produce IL-18 and cells that express IL-18 receptors. In
experimentally induced diabetes, islet failure correlates with IL-18 levels and diabetes is …