Conventional laboratory housing increases morbidity and mortality in research rodents: results of a meta-analysis

J Cait, A Cait, RW Scott, CB Winder, GJ Mason - BMC biology, 2022 - Springer
Background Over 120 million mice and rats are used annually in research, conventionally
housed in shoebox-sized cages that restrict natural behaviours (eg nesting and burrowing) …

[HTML][HTML] How much'enrichment'is enough for laboratory rodents? A systematic review and meta-analysis re-assessing the impact of well-resourced cages on morbidity …

J Cait, CB Winder, GJ Mason - Applied Animal Behaviour Science, 2024 - Elsevier
Laboratory rodent housing often fails to meet rodents' behavioral and physiological needs.
We previously found that compared to well-resourced (often called 'enriched') housing …

Neurobiology of pathogen avoidance and mate choice: Current and future directions

D Cantini, E Choleris, M Kavaliers - Animals, 2024 - mdpi.com
Simple Summary The risk of parasitic infection has a major influence on animal behaviour.
Organisms must adjust their behaviour to avoid various modes of parasitic infection and …

Waking inactivity as a welfare indicator in laboratory mice: investigating postures, facial expressions and depression-like states

A MacLellan, B Nazal, L Young… - Royal Society open …, 2022 - royalsocietypublishing.org
Animal welfare assessment relies on valid and practical indicators of affect. In mice, the most
widely used research vertebrates, lying still with eyes open, inactive-but-awake (IBA) in the …

The laboratory mouse: Biology, behaviour, enrichment and welfare: first principles and real solutions for laboratory mice

KR Pritchett‐Corning, JP Garner - The UFAW Handbook on the …, 2024 - Wiley Online Library
This chapter illustrates the detailed steps and understanding required to avoid preventable
welfare impacts of housing and husbandry, monitor for physical and behavioural health …

An overview of behavioral management for laboratory animals

SJ Schapiro - Behavioral Biology of Laboratory Animals, 2021 - taylorfrancis.com
This chapter provides a “big picture” view of the value of implementing behavioral
management programs for animals in captivity, especially those that are likely to be involved …

Implications of Conventional Laboratory Housing for Rodent Health, Welfare and Scientific Validity

J Cait - 2023 - atrium.lib.uoguelph.ca
Biomedical research relies heavily on mice and rats as animal models for studying human
diseases. To ensure this research is conducted ethically, research benefits should exceed …

[PDF][PDF] The impact of social isolation on laboratory rodent health: a protocol for a systematic review

J Cait, MT Avey, GJ Mason - 2024 - atrium.lib.uoguelph.ca
1 Title: The impact of social isolation on laboratory rodent health: a protocol for a systematic
review. Authors: Jessica Cait1, Page 1 1 Title: The impact of social isolation on laboratory …

Do conventional cages make laboratory mice depressed? A framework for identifying animal depression

A MacLellan - 2023 - atrium.lib.uoguelph.ca
For decades, parallels have been drawn between animals in suboptimal conditions and
humans experiencing clinical depression. This is true of biomedical research using animals …

[PDF][PDF] Interactive effects of experimental outcomes and laboratory rodent housing: a protocol for a systematic review

J Cait, CB Winder, GJ Mason - 2022 - atrium.lib.uoguelph.ca
Rationale: Over 120 million rodents are used in research each year globally [2-4], most of
which are housed in barren shoebox-sized cages, often containing little more than food …