Over the last decade, it has been increasingly demonstrated that the genomes of many
species are pervasively transcribed, resulting in the production of numerous long noncoding …

Noncoding RNAs (ncRNAs) constitute the majority of the human transcribed genome. This
largest class of RNA transcripts plays diverse roles in a multitude of cellular processes, and …

RNA is not only a messenger operating between DNA and protein. Transcription of
essentially the entire eukaryotic genome generates a myriad of non-protein-coding RNA …

Abstract The RNA World Hypothesis suggests that prebiotic life revolved around RNA
instead of DNA and proteins. Although modern cells have changed significantly in 4 billion …

X-chromosome inactivation (XCI) is the epigenetic mechanism that ensures X-linked dosage
compensation between cells of females (XX karyotype) and males (XY). XCI is essential for …

Long non-coding RNAs (lncRNAs) have been found to perform various functions in a wide
variety of important biological processes. To make easier interpretation of lncRNA …

Over the past decade, it has become clear that mammalian genomes encode thousands of
long non-coding RNAs (lncRNAs), many of which are now implicated in diverse biological …

X chromosome inactivation in mammalian females results in the cis-limited transcriptional
inactivity of most of the genes on one X chromosome. The X/ST gene is unique among X …

Long non-coding RNAs (lncRNAs) regulate gene expression in a variety of ways at
epigenetic, chromatin remodeling, transcriptional, and translational levels. Accumulating …

The **st gene has been proposed as a candidate for the X inactivation centre, the master
regulatory switch locus that controls X chromosome inactivation. So far this hypothesis has …