Transcription factors (TFs) are thought to function with partners to achieve specificity and
precise quantitative outputs. In the develo** heart, heterotypic TF interactions, such as …

Transmission of Plasmodium falciparum and other malaria parasites requires their
differentiation from asexual blood stages into gametocytes, the non-replicative sexual stage …

Bicuspid aortic valve (BAV) is the most common form of congenital cardiovascular defect in
humans and is associated with substantial morbidity and mortality. Emerging evidence …

Background—The transcription factor NKX2-5 is crucial for heart development, and
mutations in this gene have been implicated in diverse congenital heart diseases and …

Homeodomains (HDs) are the second largest class of DNA binding domains (DBDs) among
eukaryotic sequence-specific transcription factors (TFs) and are the TF structural class with …

Genome-wide association studies (GWAS) have mapped over 90% of disease-or trait-
associated variants within the non-coding genome, like cis-regulatory elements (CREs). Non …

Homeodomain transcription factors (TFs) bind to specific DNA sequences to regulate the
expression of target genes. Structural work has provided insight into molecular identities and …

Sonic hedgehog (Shh) signaling patterns the vertebrate spinal cord by activating a group of
transcriptional repressors in distinct neural progenitors of somatic motor neuron and …

Background—Heterozygous human mutations of NKX2-5 are highly penetrant and
associated with varied congenital heart defects. The heterozygous knockout of murine Nkx2 …

Background: Dilated cardiomyopathy (DCM) is an important cause of heart failure. Variants
in> 50 genes have been reported to cause DCM, but causative variants have been found in …