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Challenges and applications of large language models
Large Language Models (LLMs) went from non-existent to ubiquitous in the machine
learning discourse within a few years. Due to the fast pace of the field, it is difficult to identify …
learning discourse within a few years. Due to the fast pace of the field, it is difficult to identify …
AI-powered therapeutic target discovery
Disease modeling and target identification are the most crucial initial steps in drug
discovery, and influence the probability of success at every step of drug development …
discovery, and influence the probability of success at every step of drug development …
The UCSC genome browser database: 2023 update
Abstract The UCSC Genome Browser (https://genome. ucsc. edu) is an omics data
consolidator, graphical viewer, and general bioinformatics resource that continues to serve …
consolidator, graphical viewer, and general bioinformatics resource that continues to serve …
A complete telomere-to-telomere assembly of the maize genome
J Chen, Z Wang, K Tan, W Huang, J Shi, T Li, J Hu… - Nature …, 2023 - nature.com
A complete telomere-to-telomere (T2T) finished genome has been the long pursuit of
genomic research. Through generating deep coverage ultralong Oxford Nanopore …
genomic research. Through generating deep coverage ultralong Oxford Nanopore …
The complete sequence of a human Y chromosome
The human Y chromosome has been notoriously difficult to sequence and assemble
because of its complex repeat structure that includes long palindromes, tandem repeats and …
because of its complex repeat structure that includes long palindromes, tandem repeats and …
CADD v1. 7: using protein language models, regulatory CNNs and other nucleotide-level scores to improve genome-wide variant predictions
Abstract Machine Learning-based scoring and classification of genetic variants aids the
assessment of clinical findings and is employed to prioritize variants in diverse genetic …
assessment of clinical findings and is employed to prioritize variants in diverse genetic …
Method of the year: long-read sequencing
Method of the year: long-read sequencing | Nature Methods Skip to main content Thank you for
visiting nature.com. You are using a browser version with limited support for CSS. To obtain the …
visiting nature.com. You are using a browser version with limited support for CSS. To obtain the …
Ensembl 2023
Abstract Ensembl (https://www. ensembl. org) has produced high-quality genomic resources
for vertebrates and model organisms for more than twenty years. During that time, our …
for vertebrates and model organisms for more than twenty years. During that time, our …
Database resources of the National Center for Biotechnology Information in 2023
Abstract The National Center for Biotechnology Information (NCBI) provides online
information resources for biology, including the GenBank® nucleic acid sequence database …
information resources for biology, including the GenBank® nucleic acid sequence database …
YaHS: yet another Hi-C scaffolding tool
We present YaHS, a user-friendly command-line tool for the construction of chromosome-
scale scaffolds from Hi-C data. It can be run with a single-line command, requires minimal …
scale scaffolds from Hi-C data. It can be run with a single-line command, requires minimal …