Current status of xenotransplantation research and the strategies for preventing xenograft rejection
Transplantation is often the last resort for end-stage organ failures, eg, kidney, liver, heart,
lung, and pancreas. The shortage of donor organs is the main limiting factor for successful …
lung, and pancreas. The shortage of donor organs is the main limiting factor for successful …
Genetically modified pigs as organ donors for xenotransplantation
M Hryhorowicz, J Zeyland, R Słomski… - Molecular Biotechnology, 2017 - Springer
The growing shortage of available organs is a major problem in transplantology. Thus, new
and alternative sources of organs need to be found. One promising solution could be …
and alternative sources of organs need to be found. One promising solution could be …
[HTML][HTML] Long-term survival of pig-to-rhesus macaque renal xenografts is dependent on CD4 T cell depletion
SC Kim, DV Mathews, CP Breeden… - American Journal of …, 2019 - Elsevier
The shortage of available organs remains the greatest barrier to expanding access to
transplant. Despite advances in genetic editing and immunosuppression, survival in …
transplant. Despite advances in genetic editing and immunosuppression, survival in …
Pre‐transplant antibody screening and anti‐CD154 costimulation blockade promote long‐term xenograft survival in a pig‐to‐primate kidney transplant model
L Higginbotham, D Mathews, CA Breeden… - …, 2015 - Wiley Online Library
Xenotransplantation has the potential to alleviate the organ shortage that prevents many
patients with end‐stage renal disease from enjoying the benefits of kidney transplantation …
patients with end‐stage renal disease from enjoying the benefits of kidney transplantation …
Progress in pig‐to‐non‐human primate transplantation models (1998–2013): a comprehensive review of the literature
DKC Cooper, V Satyananda, B Ekser… - …, 2014 - Wiley Online Library
Background The pig‐to‐non‐human primate model is the standard choice for in vivo studies
of organ and cell xenotransplantation. In 1998, Lambrigts and his colleagues surveyed the …
of organ and cell xenotransplantation. In 1998, Lambrigts and his colleagues surveyed the …
Selected physiologic compatibilities and incompatibilities between human and porcine organ systems
Z Ibrahim, J Busch, M Awwad, R Wagner… - …, 2006 - Wiley Online Library
The shortage of donor organs is a major barrier to clinical organ transplantation. Although
xenotransplantation is considered one of the alternatives to human organ transplantation …
xenotransplantation is considered one of the alternatives to human organ transplantation …
Genome editing in large animals: current status and future prospects
Large animals (non-human primates, livestock and dogs) are playing important roles in
biomedical research, and large livestock animals serve as important sources of meat and …
biomedical research, and large livestock animals serve as important sources of meat and …
Efficient production by sperm-mediated gene transfer of human decay accelerating factor (hDAF) transgenic pigs for xenotransplantation
A large number of hDAF transgenic pigs to be used for xenotransplantation research were
generated by using sperm-mediated gene transfer (SMGT). The efficiency of transgenesis …
generated by using sperm-mediated gene transfer (SMGT). The efficiency of transgenesis …
The immunological barrier to xenotransplantation
The transplantation of cells, tissue, or organs between the host. However, diversity of
antigens is not sufficient disparate species, that is,“xenotransplantation,” has to explain the …
antigens is not sufficient disparate species, that is,“xenotransplantation,” has to explain the …
Xenotransplantation of solid organs in the pig-to-primate model
Xenotransplantation using pig organs could solve the significant increasing shortage of
donor organs for allotransplantation. In the last two decades, major progress has been made …
donor organs for allotransplantation. In the last two decades, major progress has been made …