Phospholipase A2 myotoxins from Bothrops snake venoms
Several myotoxins have been isolated from Bothrops snake venoms during the last 10
years. All of them are group II basic phospholipases A2, although some lack enzymatic …
years. All of them are group II basic phospholipases A2, although some lack enzymatic …
Skeletal muscle degeneration induced by venom phospholipases A2: insights into the mechanisms of local and systemic myotoxicity
JM Gutiérrez, CL Ownby - Toxicon, 2003 - Elsevier
Local and systemic skeletal muscle degeneration is a common consequence of
envenomations due to snakebites and mass bee attacks. Phospholipases A2 (PLA2) are …
envenomations due to snakebites and mass bee attacks. Phospholipases A2 (PLA2) are …
Phospholipase A2—a structural review
Phospholipases A2 (PLA2) are widely distributed in nature and are well characterized
proteins with respect to their catalytic and pharmacological activities. A wealth of structural …
proteins with respect to their catalytic and pharmacological activities. A wealth of structural …
Ophidian envenomation strategies and the role of purines
SD Aird - Toxicon, 2002 - Elsevier
Snake envenomation employs three well integrated strategies: prey immobilization via
hypotension, prey immobilization via paralysis, and prey digestion. Purines (adenosine …
hypotension, prey immobilization via paralysis, and prey digestion. Purines (adenosine …
An overview of lysine-49 phospholipase A2 myotoxins from crotalid snake venoms and their structural determinants of myotoxic action
B Lomonte, Y Angulo, L Calderón - Toxicon, 2003 - Elsevier
In 1984, the first venom phospholipase A2 (PLA2) with a lysine substituting for the highly
conserved aspartate 49 was discovered, in the North American crotalid snake Agkistrodon p …
conserved aspartate 49 was discovered, in the North American crotalid snake Agkistrodon p …
Lys49 myotoxins, secreted phospholipase A2-like proteins of viperid venoms: A comprehensive review
B Lomonte - Toxicon, 2023 - Elsevier
Muscle necrosis is a potential clinical complication of snakebite envenomings, which in
severe cases can lead to functional or physical sequelae such as disability or amputation …
severe cases can lead to functional or physical sequelae such as disability or amputation …
Catalytically Active Snake Venom PLA2 Enzymes: An Overview of Its Elusive Mechanisms of Reaction: Miniperspective
J Castro-Amorim, A Novo de Oliveira… - Journal of Medicinal …, 2023 - ACS Publications
Snake venom-secreted phospholipase A2 (svPLA2) enzymes, both catalytically active and
inactive, are a central component in envenoming. These are responsible for disrupting the …
inactive, are a central component in envenoming. These are responsible for disrupting the …
Inflammatory effects of snake venom myotoxic phospholipases A2
Snake venom phospholipases A2 (PLA2) show a remarkable functional diversity. Among
their toxic activities, some display the ability to cause rapid necrosis of skeletal muscle fibers …
their toxic activities, some display the ability to cause rapid necrosis of skeletal muscle fibers …
Host response toBothrops asper snake venom: Analysis of edema formation, inflammatory cells, and cytokine release in a mouse model
B Lomonte, A Tarkowski, LÅ Hanson - Inflammation, 1993 - Springer
As part of the characterization of the host reactivity to the venom of Bothrops asper, we
investigated the inflammatory responses in the mouse footpad model. The subcutaneously …
investigated the inflammatory responses in the mouse footpad model. The subcutaneously …
Experimental pathology of local tissue damage induced by Bothrops asper snake venom
Envenomations by Bothrops asper are often associated with complex and severe local
pathological manifestations, including edema, blistering, dermonecrosis, myonecrosis and …
pathological manifestations, including edema, blistering, dermonecrosis, myonecrosis and …