The C-type lectins are a superfamily of proteins that recognize a broad repertoire of ligands
and that regulate a diverse range of physiological functions. Most research attention has …

The major innate immune cell types involved in tuberculosis (TB) infection are
macrophages, dendritic cells (DCs), neutrophils and natural killer (NK) cells. These immune …

Tuberculosis remains one of the leading causes of mortality worldwide, and, despite its
clinical significance, there are still significant gaps in our understanding of pathogenic and …

Metabolic reprogramming powers and polarizes macrophage functions, but the nature and
regulation of this response during infection with pathogens remain controversial. In this …

C-type lectin receptors (CLRs) are important pattern recognition receptors involved in
recognition and induction of adaptive immunity to pathogens. Certain CLRs play an …

The mononuclear phagocyte system (MPS) is a family of cells including progenitors,
circulating blood monocytes, resident tissue macrophages, and dendritic cells (DCs) present …

Macrophages are integral to the pathogenesis of atherosclerosis, but the contribution of
distinct macrophage subsets to disease remains poorly defined. Using single cell …

Over the last decade, C-type lectin-like receptors (CTLRs), expressed mostly by myeloid
cells, have gained increasing attention for their role in the fine tuning of both innate and …

C-type lectin-like receptors (CLRs) represent a family of transmembrane pattern recognition
receptors, expressed primarily by myeloid cells. They recognize not only pathogen moieties …

Fungi can cause disease in humans, from mucocutaneous to life-threatening systemic
infections. Initiation of antifungal immunity involves fungal recognition by pattern recognition …