Drug delivery technologies have enabled the development of many pharmaceutical
products that improve patient health by enhancing the delivery of a therapeutic to its target …

Gene therapy is a promising strategy for the treatment of monogenic disorders. Non-viral
gene delivery systems including lipid-based DNA therapeutics offer the opportunity to …

Cancer therapy has been characterized throughout history by ups and downs, not only due
to the ineffectiveness of treatments and side effects, but also by hope and the reality of …

Gene transfer methods are promising in the field of gene therapy. Current methods for gene
transfer include three major groups: viral, physical and chemical methods. This review …

Gene therapy has gained significant attention over the past two decades as a potential
method for treating genetic disorders such as severe combined immunodeficiency, 1 cystic …

Fifteen years ago, the drive to study retroviruses was rooted principally in the traditional goal
of using animal models to understand human cancer. The historical importance of …

Since the discovery, over a decade and a half ago, that genetically engineered DNA can be
delivered in vaccine form and elicit an immune response, there has been much progress in …

Lipid‐based nanoparticles have emerged as a clinically viable platform technology to
deliver nucleic acids for a wide range of healthcare applications. Within this scope, one of …

Since the first published examination of poly (ethylenimine)(PEI) as a gene delivery vehicle,
there has been a flurry of research aimed at this polycation and its role in gene therapy …

Cationic liposomes complexed with DNA (CL-DNA) are promising synthetically based
nonviral carriers of DNA vectors for gene therapy. The solution structure of CL-DNA …