Neuroaxonal damage is the pathological substrate of permanent disability in various
neurological disorders. Reliable quantification and longitudinal follow-up of such damage …

Proteins are the major component of the living cell. They play crucial roles in the
maintenance of life, and their dysfunctions are known to cause different pathologies. One of …

Interest in neurofilaments has risen sharply in recent years with recognition of their potential
as biomarkers of brain injury or neurodegeneration in CSF and blood. This is in the context …

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease among
adults. With diagnosis reached relatively late into the disease process, extensive motor cell …

Motor neuron diseases (MNDs) are etiologically and biologically heterogeneous diseases.
The pathobiology of motor neuron degeneration is still largely unknown, and no effective …

Neurofilament proteins (Nf) have been validated and established as a reliable body fluid
biomarker for neurodegenerative pathology. This review covers seven Nf isoforms, Nf light …

Studies on the assembly of neuronal intermediate filaments (IFs) date back to the early work
of Alzheimer. Develo** neurons express a series of IF proteins, sequentially, at distinct …

Anionic polyelectrolyte filaments are common in biological cells. DNA, RNA, the cytoskeletal
filaments F-actin, microtubules, and intermediate filaments, and polysaccharides such as …

Introduction 2.1. Neurodegenerative diseases as proteinopathies 2.2. Neurodegenerative
diseases as amyloidoses 2.3. Prion-like propagation of neurodegenerative diseases 2.4 …

Intermediate filaments (IFs), important components of the cytoskeleton, provide a versatile,
tunable network of self-assembled proteins. IF proteins contain three distinct domains: an α …