Cognitive impairment after ischemic and hemorrhagic stroke: a scientific statement from the American Heart Association/American Stroke Association

N El Husseini, IL Katzan, NS Rost, ML Blake, E Byun… - Stroke, 2023 - ahajournals.org
Purpose: Cognitive impairment is a common consequence of stroke and has direct
implications for poststroke functioning and quality of life, including the ability to maintain a …

Cognitive impairment and dementia after stroke: design and rationale for the DISCOVERY study

NS Rost, JF Meschia, R Gottesman, L Wruck, K Helmer… - Stroke, 2021 - ahajournals.org
Stroke is a leading cause of the adult disability epidemic in the United States, with a major
contribution from poststroke cognitive impairment and dementia (PSCID), the rates of which …

Molecular mechanisms of neuronal death in brain injury after subarachnoid hemorrhage

J Chen, M Li, Z Liu, Y Wang, K **ong - Frontiers in cellular …, 2022 - frontiersin.org
Subarachnoid haemorrhage (SAH) is a common cerebrovascular disease with high
disability and mortality rates worldwide. The pathophysiological mechanisms involved in an …

Effects of clazosentan on cerebral vasospasm–related morbidity and all-cause mortality after aneurysmal subarachnoid hemorrhage: two randomized phase 3 trials in …

H Endo, Y Hagihara, N Kimura, K Takizawa… - Journal of …, 2022 - thejns.org
OBJECTIVE Clazosentan has been investigated globally for the prevention of cerebral
vasospasm after aneurysmal subarachnoid hemorrhage (aSAH). The authors evaluated its …

The role of nitric oxide in stroke

Z Chen, R Mou, D Feng, Z Wang, G Chen - Medical gas research, 2017 - journals.lww.com
Stroke is considered to be an acute cerebrovascular disease, including ischemic stroke and
hemorrhagic stroke. The high incidence and poor prognosis of stroke suggest that it is a …

Predictors of in-hospital death after aneurysmal subarachnoid hemorrhage: analysis of a nationwide database (Swiss SOS [Swiss Study on Aneurysmal Subarachnoid …

MN Stienen, M Germans, JK Burkhardt, MC Neidert… - Stroke, 2018 - ahajournals.org
Background and Purpose—To identify predictors of in-hospital mortality in patients with
aneurysmal subarachnoid hemorrhage and to estimate their impact. Methods …

Cognitive deficits among patients surviving aneurysmal subarachnoid hemorrhage. A contemporary systematic review

ES Nussbaum, N Mikoff… - British Journal of …, 2021 - Taylor & Francis
Background Subarachnoid hemorrhage (SAH) is associated with high rates of morbidity,
including neurological and cognitive deficits that may be difficult to identify and quantify. This …

The REACT study: design of a randomized phase 3 trial to assess the efficacy and safety of clazosentan for preventing deterioration due to delayed cerebral ischemia …

N Bruder, R Higashida, H Santin-Janin, C Dubois… - BMC neurology, 2022 - Springer
Background For patients presenting with an aneurysmal subarachnoid hemorrhage (aSAH),
delayed cerebral ischemia (DCI) is a significant cause of morbidity and mortality. The …

[HTML][HTML] Interleukin 6 and aneurysmal subarachnoid hemorrhage. A narrative review

M Simon, A Grote - International Journal of Molecular Sciences, 2021 - mdpi.com
Interleukin 6 (IL-6) is a prominent proinflammatory cytokine. Neuroinflammation in general,
and IL-6 signaling in particular, appear to play a major role in the pathobiology and …

REACT: a randomized trial to assess the efficacy and safety of clazosentan for preventing clinical deterioration due to delayed cerebral ischemia after aneurysmal …

SA Mayer, N Bruder, G Citerio, L Defreyne… - Journal of …, 2024 - thejns.org
OBJECTIVE Ischemic complications account for significant patient morbidity following
aneurysmal subarachnoid hemorrhage (aSAH). The Prevention and Treatment of …