Understanding 3D genome organization by multidisciplinary methods
Understanding how chromatin is folded in the nucleus is fundamental to understanding its
function. Although 3D genome organization has been historically difficult to study owing to a …
function. Although 3D genome organization has been historically difficult to study owing to a …
[HTML][HTML] Spatial and temporal organization of the genome: Current state and future aims of the 4D nucleome project
The four-dimensional nucleome (4DN) consortium studies the architecture of the genome
and the nucleus in space and time. We summarize progress by the consortium and highlight …
and the nucleus in space and time. We summarize progress by the consortium and highlight …
Computational methods for analysing multiscale 3D genome organization
Recent progress in whole-genome map** and imaging technologies has enabled the
characterization of the spatial organization and folding of the genome in the nucleus. In …
characterization of the spatial organization and folding of the genome in the nucleus. In …
HIV-1 usurps mixed-charge domain-dependent CPSF6 phase separation for higher-order capsid binding, nuclear entry and viral DNA integration
S Jang, GJ Bedwell, SP Singh, HJ Yu… - Nucleic Acids …, 2024 - academic.oup.com
HIV-1 integration favors nuclear speckle (NS)-proximal chromatin and viral infection induces
the formation of capsid-dependent CPSF6 condensates that colocalize with nuclear …
the formation of capsid-dependent CPSF6 condensates that colocalize with nuclear …
The chromosome folding problem and how cells solve it
Every cell must solve the problem of how to fold its genome. We describe how the folded
state of chromosomes is the result of the combined activity of multiple conserved …
state of chromosomes is the result of the combined activity of multiple conserved …