The endoplasmic reticulum (ER) is a major organelle involved in protein quality control and
cellular homeostasis. ER stress results from structural and functional dysfunction of the …

Over the last decade, sigma-1 receptor (Sig1R) has been recognized as a valid target for the
treatment of seizure disorders and seizure-related comorbidities. Clinical trials with Sig1R …

Ochratoxin A (OTA), a secondary fungal metabolite with nephrotoxicity, is widespread in
numerous kinds of feeds and foodstuffs. Ursolic acid (UA), a water-insoluble pentacyclic …

Rough endoplasmic reticulum (ER) sheets are a fundamental domain of the ER and the
gateway into the secretory pathway. Although reticulon proteins stabilize high-curvature ER …

Organelle contact sites are multifunctional platforms for maintaining cellular homeostasis.
Alternations of the mitochondria-associated membranes (MAM), one of the organelle contact …

Cardiovascular and renal diseases are among the leading causes of death worldwide, and
regardless of current efforts, there is a demanding need for therapeutic alternatives to …

Parkinson's disease is a neurodegenerative disease affecting mainly the elderly population.
It is characterized by the loss of dopaminergic neurons of the substantia nigra pars …

Modern pharmacotherapy of neurodegenerative diseases is predominantly symptomatic
and does not allow vicious circles causing disease development to break. Protein misfolding …

Though a great many of studies on the development of antidepressants for the therapy of
major depression disorder (MDD) and the development of antidepressants have been …

Abstract Sigma-1 receptor (S1R) is a unique multi-tasking chaperone protein in the
endoplasmic reticulum. Since S1R agonists exhibit potent antidepressant-like activity, S1R …