International Union of Basic and Clinical Pharmacology. CVI: GABAA receptor subtype-and function-selective ligands: key issues in translation to humans
GABA A receptors are the major inhibitory transmitter receptors in the brain. They are ligand-
gated chloride channels and the site of action of benzodiazepines, barbiturates, neuroactive …
gated chloride channels and the site of action of benzodiazepines, barbiturates, neuroactive …
[HTML][HTML] Hippocampal NMDA receptors and anxiety: at the interface between cognition and emotion
David De Wied had a fundamental interest in the brain and behaviour, with a particular
interest in the interface between cognition and emotion, and how impairments at this …
interest in the interface between cognition and emotion, and how impairments at this …
Mechanisms of action and persistent neuroplasticity by drugs of abuse
ER Korpi, B den Hollander, U Farooq… - Pharmacological …, 2015 - Elsevier
Adaptation of the nervous system to different chemical and physiologic conditions is
important for the homeostasis of brain processes and for learning and remembering …
important for the homeostasis of brain processes and for learning and remembering …
Properties of slow oscillation during slow-wave sleep and anesthesia in cats
Deep anesthesia is commonly used as a model of slow-wave sleep (SWS). Ketamine–
xylazine anesthesia reproduces the main features of sleep slow oscillation: slow, large …
xylazine anesthesia reproduces the main features of sleep slow oscillation: slow, large …
HCN1 channel subunits are a molecular substrate for hypnotic actions of ketamine
X Chen, S Shu, DA Bayliss - Journal of Neuroscience, 2009 - Soc Neuroscience
Ketamine has important anesthetic, analgesic, and psychotropic actions. It is widely believed
that NMDA receptor inhibition accounts for ketamine actions, but there remains a dearth of …
that NMDA receptor inhibition accounts for ketamine actions, but there remains a dearth of …
GABAA receptors and the diversity in their structure and pharmacology
Abstract GABA A receptors (GABA A Rs) are a class of ligand-gated ion channels with high
physiological and therapeutic significance. In the brain, these pentameric receptors occur …
physiological and therapeutic significance. In the brain, these pentameric receptors occur …
Antidepressant-like effects of low ketamine dose is associated with increased hippocampal AMPA/NMDA receptor density ratio in female Wistar–Kyoto rats
Y Tizabi, BH Bhatti, KF Manaye, JR Das, L Akinfiresoye - Neuroscience, 2012 - Elsevier
Preclinical as well as limited clinical studies indicate that ketamine, a non-competitive
glutamate N-methyl-d-aspartate (NMDA) receptor antagonist, may exert a quick and …
glutamate N-methyl-d-aspartate (NMDA) receptor antagonist, may exert a quick and …
Ketamine enantiomers in the rapid and sustained antidepressant effects
Recent evidence has suggested that the N-methyl-D-aspartate receptor antagonist ketamine
shows significant therapeutic effects in major depression and bipolar disorder. This effect is …
shows significant therapeutic effects in major depression and bipolar disorder. This effect is …
Therapeutic potential of ketamine for alcohol use disorder
Excessive alcohol consumption is involved in 1/10 of deaths of US working-age adults and
costs the country around $250,000,000 yearly. While Alcohol Use Disorder (AUD) pathology …
costs the country around $250,000,000 yearly. While Alcohol Use Disorder (AUD) pathology …
Tonic inhibition enhances fidelity of sensory information transmission in the cerebellar cortex
Tonic inhibition is a key regulator of neuronal excitability and network function in the brain,
but its role in sensory information processing remains poorly understood. The cerebellum is …
but its role in sensory information processing remains poorly understood. The cerebellum is …