Skeletal metastases are frequent complications of many cancers, causing bone
complications (fractures, bone pain, disability) that negatively affect the patient's quality of …

The intestinal extracellular matrix (ECM) represents a complex network of proteins that not
only forms a support structure for resident cells but also interacts closely with them by …

Tumour dormancy and recurrent metastatic cancer remain the greatest clinical challenge for
cancer patients. Dormant tumour cells can evade treatment and detection, while retaining …

Breast cancer is the most frequent cancer among women worldwide. Therapeutic strategies
to prevent or treat metastatic disease are still inadequate although great progress has been …

Breast cancer is a complex disease exhibiting a great degree of heterogeneity due to
different molecular subtypes. Notch signaling regulates the differentiation of breast epithelial …

Bone metastasis occurs when tumour cells dissociate from primary tumours, enter the
circulation (circulating tumour cells, CTCs), and colonize sites in bone (disseminated tumour …

Cancer cell dormancy is a common feature of human tumors and represents a major clinical
barrier to the long-term efficacy of anticancer therapies. Dormant cancer cells, either in …

The establishment of bone metastasis remains one of the most frequent complications of
patients suffering from advanced breast cancer. Patients with bone metastases experience …

Metastasis and relapse account for the great majority of cancer-related deaths. Most
metastatic lesions are micro metastases that have the capacity to remain in a non-dividing …

Distant recurrences occurring years after removal of the primary tumor arise from
disseminated tumor cells (DTCs) that lie dormant (quiescent/asymptomatic) until they …