Effect of the in vitro gastrointestinal digestion on free-phenolic compounds and mono/oligosaccharides from Moringa oleifera leaves: Bioaccessibility, intestinal …

LH Caicedo-Lopez, I Luzardo-Ocampo… - Food Research …, 2019 - Elsevier
Moringa oleifera is a plant recognized for its compounds such as dietary fiber
(oligosaccharides, amongst others) and polyphenols, with biological activities. These …

Bioaccessibility and antioxidant activity of free phenolic compounds and oligosaccharides from corn (Zea mays L.) and common bean (Phaseolus vulgaris L.) chips …

I Luzardo-Ocampo, R Campos-Vega… - Food Research …, 2017 - Elsevier
Corn (Zea mays L.) and common beans (Phaseolus vulgaris L.) are alternative suitable
ingredients for snacks, because of their content of bioactive compounds such as phenolic …

The progress on sulfhydryl modified polymers with regard to synthesis, characterization and mucoadhesion

ES Armengol, F Laffleur - International Journal of Pharmaceutics, 2021 - Elsevier
The concepts of mucoadhesion and mucoadhesive polymers were introduced in the 20th
century, leading to several advantages. These included enhanced drug absorption and …

Transferrin Aptamers Increase the In Vivo Blood–Brain Barrier Targeting of Protein Spherical Nucleic Acids

CD Kusmierz, CE Callmann, S Kudruk… - Bioconjugate …, 2022 - ACS Publications
The systemic delivery of exogenous proteins to cells within the brain and central nervous
system (CNS) is challenging due to the selective impermeability of the blood–brain barrier …

Retinal delivery of the protein kinase C-β inhibitor ruboxistaurin using non-invasive nanoparticles of polyamidoamine dendrimers

RA Alshammari, FS Aleanizy, A Aldarwesh… - Pharmaceutics, 2022 - mdpi.com
Ruboxistaurin (RBX) is an anti-vascular endothelial growth factor (anti-VEGF) agent that is
used in the treatment of diabetic retinopathy and is mainly given intravitreally. To provide a …

GM1 oligosaccharide crosses the human blood–brain barrier in vitro by a paracellular route

E Di Biase, G Lunghi, M Maggioni, M Fazzari… - International Journal of …, 2020 - mdpi.com
Ganglioside GM1 (GM1) has been reported to functionally recover degenerated nervous
system in vitro and in vivo, but the possibility to translate GM1′ s potential in clinical …

[HTML][HTML] Stable nanoemulsions for poorly soluble curcumin: From production to digestion response in vitro

Q Ye, S Kwon, Z Gu, C Selomulya - Journal of Molecular Liquids, 2024 - Elsevier
Curcumin, a polyphenol, can induce anticancer activity depending on dose. However, oral
curcumin administration is limited by its low bioavailability due to aqueous insolubility and …

Droplet-interface-bilayer assays in microfluidic passive networks

B Schlicht, M Zagnoni - Scientific reports, 2015 - nature.com
Basic biophysical studies and pharmacological processes can be investigated by mimicking
the intracellular and extracellular environments across an artificial cell membrane construct …

Validation of an ex vivo permeation method for the intestinal permeability of different BCS drugs and its correlation with Caco-2 in vitro experiments

A B. Sánchez, A C. Calpena, M Mallandrich, B Clares - Pharmaceutics, 2019 - mdpi.com
The absorption study of drugs through different biological membranes constitutes an
essential step in the development of new pharmaceutical dosage forms. Concerning orally …

Bioaccessibility during In Vitro Digestion and Antiproliferative Effect of Bioactive Compounds from Andean Berry (Vaccinium meridionale Swartz) Juice

CD Agudelo, I Luzardo-Ocampo… - Journal of Agricultural …, 2018 - ACS Publications
Berry consumption is associated with colorectal-cancer chemoprevention, but digestive
conditions can affect this property. The bioaccessibility and apparent permeability …