Abstract H3K27M-mutant diffuse midline gliomas (DMGs) express high levels of the
disialoganglioside GD2 (ref.). Chimeric antigen receptor-modified T cells targeting GD2 …

As global life expectancy increases, age-related brain diseases such as stroke and
dementia have become leading causes of death and disability. The aging of the …

Two major functions of the lymphatic system are the reabsorption of excess interstitial
fluid/protein and the coordination of immune cell interactions and trafficking. Specialized …

Our understanding of the meningeal immune system has recently burgeoned, particularly
regarding how innate and adaptive effector cells are mobilized to meet brain challenges …

Ischemic stroke and vascular cognitive impairment, caused by a sudden arterial occlusion or
more subtle but protracted vascular insufficiency, respectively, are leading causes of …

Migraine is a highly prevalent and disabling pain disorder that affects> 1 billion people
worldwide. One central hypothesis points to the cranial meninges as a key site underlying …

Migraines are a type of headache that occur with other neurological symptoms, but the
pathophysiology remains unclear. In this issue of the JCI, Nelson-Maney and authors used …

The brain has traditionally been considered an “immune-privileged” organ lacking a
lymphatic system. However, recent studies have challenged this view by identifying the …

Our knowledge about the meningeal immune system has recently burgeoned, particularly
our understanding of how innate and adaptive effector cells are mobilized to meet brain …

脑小血管病(cSVD) 是一种常见的脑血管疾病, 与认知障碍之间存在显著关联.
**年脑类淋巴系统(GS) 和硬脑膜淋巴管(mLVs) 的研究为理解cSVD 及其导致的认知障碍提供了 …