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Enteric nervous system development: migration, differentiation, and disease
The enteric nervous system (ENS) provides the intrinsic innervation of the bowel and is the
most neurochemically diverse branch of the peripheral nervous system, consisting of two …
most neurochemically diverse branch of the peripheral nervous system, consisting of two …
The cohesin complex and its roles in chromosome biology
JM Peters, A Tedeschi, J Schmitz - Genes & development, 2008 - genesdev.cshlp.org
Cohesin is a chromosome-associated multisubunit protein complex that is highly conserved
in eukaryotes and has close homologs in bacteria. Cohesin mediates cohesion between …
in eukaryotes and has close homologs in bacteria. Cohesin mediates cohesion between …
The lncRNA Malat1 is dispensable for mouse development but its transcription plays a cis-regulatory role in the adult
Genome-wide studies have identified thousands of long noncoding RNAs (lncRNAs) lacking
protein-coding capacity. However, most lncRNAs are expressed at a very low level, and in …
protein-coding capacity. However, most lncRNAs are expressed at a very low level, and in …
Cohesin mediates transcriptional insulation by CCCTC-binding factor
Cohesin complexes mediate sister-chromatid cohesion in dividing cells but may also
contribute to gene regulation in postmitotic cells. How cohesin regulates gene expression is …
contribute to gene regulation in postmitotic cells. How cohesin regulates gene expression is …
[HTML][HTML] Cohesins functionally associate with CTCF on mammalian chromosome arms
Cohesins mediate sister chromatid cohesion, which is essential for chromosome
segregation and postreplicative DNA repair. In addition, cohesins appear to regulate gene …
segregation and postreplicative DNA repair. In addition, cohesins appear to regulate gene …
Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus
S Hadjur, LM Williams, NK Ryan, BS Cobb, T Sexton… - Nature, 2009 - nature.com
Cohesin-mediated sister chromatid cohesion is essential for chromosome segregation and
post-replicative DNA repair,. In addition, evidence from model organisms,,, and from human …
post-replicative DNA repair,. In addition, evidence from model organisms,,, and from human …
A CTCF-independent role for cohesin in tissue-specific transcription
D Schmidt, PC Schwalie, CS Ross-Innes… - Genome …, 2010 - genome.cshlp.org
The cohesin protein complex holds sister chromatids in dividing cells together and is
essential for chromosome segregation. Recently, cohesin has been implicated in mediating …
essential for chromosome segregation. Recently, cohesin has been implicated in mediating …
Multiple Organ System Defects and Transcriptional Dysregulation in the Nipbl+/− Mouse, a Model of Cornelia de Lange Syndrome
S Kawauchi, AL Calof, R Santos, ME Lopez-Burks… - PLoS …, 2009 - journals.plos.org
Cornelia de Lange Syndrome (CdLS) is a multi-organ system birth defects disorder linked, in
at least half of cases, to heterozygous mutations in the NIPBL gene. In animals and fungi …
at least half of cases, to heterozygous mutations in the NIPBL gene. In animals and fungi …
Cornelia de Lange syndrome, cohesin, and beyond
J Liu, ID Krantz - Clinical genetics, 2009 - Wiley Online Library
Cornelia de Lange syndrome (CdLS)(OMIM# 122470,# 300590 and# 610759) is a dominant
genetic disorder with multiple organ system abnormalities which is classically characterized …
genetic disorder with multiple organ system abnormalities which is classically characterized …
Transcriptional Dysregulation in NIPBL and Cohesin Mutant Human Cells
J Liu, Z Zhang, M Bando, T Itoh, MA Deardorff… - PLoS …, 2009 - journals.plos.org
Cohesin regulates sister chromatid cohesion during the mitotic cell cycle with Nipped-B-Like
(NIPBL) facilitating its loading and unloading. In addition to this canonical role, cohesin has …
(NIPBL) facilitating its loading and unloading. In addition to this canonical role, cohesin has …