Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …

Alzheimer's disease (AD) is the most frequent cause of age-related neurodegeneration and
cognitive impairment, and there are currently no broadly effective therapies. The underlying …

Hepatitis B virus (HBV)-specific CD8 T cells are functionally exhausted in chronic hepatitis B
infection, and this condition can be corrected only partially through the modulation of …

Mitochondria are a major target in hypoxic/ischemic injury. Mitochondrial impairment
increases with age leading to dysregulation of molecular pathways linked to mitochondria …

The mitochondrion is at the core of cellular energy metabolism, being the site of most ATP
generation. Calcium is a key regulator of mitochondrial function and acts at several levels …

Mitochondrial oxidative damage contributes to a range of degenerative diseases.
Consequently, the selective inhibition of mitochondrial oxidative damage is a promising …

Increased understanding of the role of mitochondria under physiological and pathological
conditions parallels increased exploration of synthetic and natural compounds able to mimic …

Oxidative stress has become widely viewed as an underlying condition in a number of
diseases, such as ischemia–reperfusion disorders, central nervous system disorders …

Tempol is a redox-cycling nitroxide that promotes the metabolism of many reactive oxygen
species (ROS) and improves nitric oxide bioavailability. It has been studied extensively in …

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are closely linked to
degenerative diseases such as Alzheimer's disease, Parkinson's, neuronal death including …