Staphylococcus aureus host interactions and adaptation

BP Howden, SG Giulieri, T Wong Fok Lung… - Nature Reviews …, 2023 - nature.com
Invasive Staphylococcus aureus infections are common, causing high mortality,
compounded by the propensity of the bacterium to develop drug resistance. S. aureus is an …

Pathogenicity and virulence of Staphylococcus aureus

GYC Cheung, JS Bae, M Otto - Virulence, 2021 - Taylor & Francis
Staphylococcus aureus is one of the most frequent worldwide causes of morbidity and
mortality due to an infectious agent. This pathogen can cause a wide variety of diseases …

Basis of virulence in enterotoxin-mediated staphylococcal food poisoning

EL Fisher, M Otto, GYC Cheung - Frontiers in microbiology, 2018 - frontiersin.org
The Staphylococcus aureus enterotoxins are a superfamily of secreted virulence factors that
share structural and functional similarities and possess potent superantigenic activity …

Novel insights into the immune response to bacterial T cell superantigens

SW Tuffs, K Dufresne, A Rishi, NR Walton… - Nature Reviews …, 2024 - nature.com
Bacterial T cell superantigens (SAgs) are a family of microbial exotoxins that function to
activate large numbers of T cells simultaneously. SAgs activate T cells by direct binding and …

[HTML][HTML] Staphylococcal superantigens: pyrogenic toxins induce toxic shock

T Krakauer - Toxins, 2019 - mdpi.com
Staphylococcal enterotoxin B (SEB) and related superantigenic toxins produced by
Staphylococcus aureus are potent activators of the immune system. These protein toxins …

Superantigen recognition and interactions: functions, mechanisms and applications

AM Deacy, SKE Gan, JP Derrick - Frontiers in Immunology, 2021 - frontiersin.org
Superantigens are unconventional antigens which recognise immune receptors outside
their usual recognition sites eg complementary determining regions (CDRs), to elicit a …

Immune Evasion by Staphylococcus aureus

NWM De Jong, KPM Van Kessel… - Microbiology …, 2019 - journals.asm.org
Staphylococcus aureus has become a serious threat to human health. In addition to having
increased antibiotic resistance, the bacterium is a master at adapting to its host by evading …

Manipulation of innate and adaptive immunity by staphylococcal superantigens

SW Tuffs, SMM Haeryfar, JK McCormick - Pathogens, 2018 - mdpi.com
Staphylococcal superantigens (SAgs) constitute a family of potent exotoxins secreted by
Staphylococcus aureus and other select staphylococcal species. SAgs function to cross-link …

Superantigens promote Staphylococcus aureus bloodstream infection by eliciting pathogenic interferon-gamma production

SW Tuffs, MI Goncheva, SX Xu, HC Craig… - Proceedings of the …, 2022 - pnas.org
Staphylococcus aureus is a foremost bacterial pathogen responsible for a vast array of
human diseases. Staphylococcal superantigens (SAgs) constitute a family of exotoxins from …

Staphylococcus aureus arsenal to conquer the lower respiratory tract

M Pivard, K Moreau, F Vandenesch - Msphere, 2021 - journals.asm.org
Staphylococcus aureus is both a commensal and a pathogenic bacterium for humans. Its
ability to induce severe infections is based on a wide range of virulence factors. S. aureus …