The sensitivity of magnetic resonance imaging to biochemical and biophysical changes in
the extracellular matrix of articular cartilage give it the potential to noninvasively detect the …

Osteoarthritis (OA) afflicts more than 20 million people in the United States and about 10% of
adults over the age of 50 years [1]. It has been demonstrated that 2.0% of women and 1.4 …

Fox et al Nov• Dec 2009 of articular cartilage thickness. The collagen fibers of this zone
(primarily, type II and IX collagen) are packed tightly and aligned parallel to the articular …

Over the last two decades, considerable progress has been reported in the field of cartilage
mechanics that impacts our understanding of the role of interstitial fluid pressurization on …

Objectives Osteoarthritis (OA) is the most prevalent chronic disease in the elderly, and it is
generally diagnosed at an advanced state when treatment is difficult if not impossible. The …

Articular cartilage (AC) has no or very low ability of self-repair, and untreated lesions may
lead to the development of osteoarthritis. One method that has been proven to result in long …

Purpose To quantify the spin‐lattice relaxation time in the rotating frame (T1ρ) in various
clinical grades of human osteoarthritis (OA) cartilage specimens obtained from total knee …

Background Rats are a widely accepted preclinical model for evaluating intervertebral disc
(IVD) degeneration and regeneration. IVD morphology is commonly assessed using …

Background: Microfracture, the standard of care, is recognized to be an incomplete solution
for cartilage damage. BST-CarGel, a chitosan-based medical device, is mixed with …

Objective Early and non-invasive detection of osteoarthritis (OA) is required to enable early
treatment and monitoring of interventions. Some of the earliest signs of OA are the change in …