RNA-binding proteins (RBPs) comprise a large class of over 2,000 proteins that interact with
transcripts in all manner of RNA-driven processes. The structures and mechanisms that …

Hydrogen-bond donors are seen to cause more problems for drug designers than hydrogen-
bond acceptors. Most of the polarity in drug-like compounds comes from hydrogen-bond …

PDBsum is a web server providing structural information on the entries in the Protein Data
Bank (PDB). The analyses are primarily image‐based and include protein secondary …

Over the past decade, the Rosetta biomolecular modeling suite has informed diverse
biological questions and engineering challenges ranging from interpretation of low …

The computational de novo protein design is increasingly applied to address a number of
key challenges in biomedicine and biological engineering. Successes in expanding …

Targeting protein kinases is an important strategy for intervention in cancer. Inhibitors are
directed at the active conformation or a variety of inactive conformations. While attempts …

Genetic defects underlying the melanocortin-4 receptor (MC4R) signaling pathway lead to
severe obesity. Three severely obese LEPR-deficient individuals were administered the …

Interactions between proteins and their ligands, such as small molecules, other proteins,
and DNA, depend on specific interatomic interactions that can be classified on the basis of …

We describe a graphical system for automatically generating multiple 2D diagrams of ligand–
protein interactions from 3D coordinates. The diagrams portray the hydrogen-bond …

Intrinsically disordered proteins (IDPs) and intrinsically disordered protein regions (IDPRs)
are functional proteins and domains that devoid stable secondary and/or tertiary structure …