Recent advances in omics technologies have led to unprecedented efforts characterizing
the molecular changes that underlie the development and progression of a wide array of …

The correlation between mRNA and protein abundances in the cell has been reported to be
notoriously poor. Recent technological advances in the quantitative analysis of mRNA and …

Differential mRNA expression studies implicitly assume that changes in mRNA expression
have biological meaning, most likely mediated by corresponding changes in protein levels …

Coexpression networks and gene regulatory networks (GRNs) are emerging as important
tools for predicting functional roles of individual genes at a system-wide scale. To enable …

The availability of complete genomic sequences and technologies that allow comprehensive
analysis of global expression profiles of messenger RNA,, have greatly expanded our ability …

Attempts to correlate protein abundance with mRNA expression levels have had variable
success. We review the results of these comparisons, focusing on yeast. In the process, we …

Proteomic analysis of complex protein mixtures using proteolytic digestion and liquid
chromatography in combination with tandem mass spectrometry is a standard approach in …

Circulating tumour cells (CTCs) are rare tumour cells found in the circulatory system of
certain cancer patients. The clinical and functional significance of CTCs is still under …

A major goal of biology is to provide a quantitative description of cellular behaviour. This
task, however, has been hampered by the difficulty in measuring protein abundances and …

We have devised an approach for analyzing shotgun proteomics datasets based on the
normalized spectral abundance factor that can be used for quantitative proteomics analysis …