Bond exchange via neighboring group-assisted reactions in dynamic covalent networks
results in efficient mechanical relaxation. In Nature, the high reactivity of RNA toward …

Abstract 31P NMR spectroscopy is a consolidated tool for the characterization of
organophosphorus compounds and, more recently, for reaction monitoring. The evolution of …

Photoactivatable protecting groups (PPGs) have become powerful materials for controlling
the activity of biologically important molecules in the biomedical field. However, designing …

Cyclative cleavage of an amine-carbamate self-immolative spacer to deliver a hydroxyl
cargo was inhibited by spacer derivatisation with a phosphate monoester handle. This …

We demonstrate a sequential nucleophilic substitution of highly electrophilic and
inexpensive phosphorus trichloride with three different alcohols in a continuous‐flow …

Amine‐carbamate self‐immolative (SI) spacers represent practical and versatile tools in
targeted prodrugs, but their slow degradation mechanism limits drug activation at the site of …

Self‐immolative (SI) spacers are degradable chemical connectors widely used in prodrugs
and drug conjugates to release pharmaceutical ingredients in response to specific stimuli …

In solid-phase oligonucleotide synthesis, a solid support modified with a universal linker is
frequently used to prepare oligonucleotides bearing non-natural-or non-nucleosides at the …

ProTides are nucleotide analogues used for the treatment of specific viral infections. These
compounds consist of a masked nucleotide that undergoes in vivo enzymatic and …

Heterocyclic drugs display diverse pharmacological activities and metabolic stability.
However, their poor solubility and pharmacokinetic properties often compromise …