[HTML][HTML] The scientific case for brain simulations

GT Einevoll, A Destexhe, M Diesmann, S Grün, V Jirsa… - Neuron, 2019 - cell.com
A key element of the European Union's Human Brain Project (HBP) and other large-scale
brain research projects is the simulation of large-scale model networks of neurons. Here, we …

A neurophysiological basis for aperiodic EEG and the background spectral trend

N Brake, F Duc, A Rokos, F Arseneau, S Shahiri… - Nature …, 2024 - nature.com
Electroencephalograms (EEGs) display a mixture of rhythmic and broadband fluctuations,
the latter manifesting as an apparent 1/f spectral trend. While network oscillations are known …

Genetic evidence for role of integration of fast and slow neurotransmission in schizophrenia

A Devor, OA Andreassen, Y Wang… - Molecular …, 2017 - nature.com
The most recent genome-wide association studies (GWAS) of schizophrenia (SCZ) identified
hundreds of risk variants potentially implicated in the disease. Further, novel statistical …

Neurophysiological dynamics of phrase-structure building during sentence processing

MJ Nelson, I El Karoui, K Giber, X Yang… - Proceedings of the …, 2017 - pnas.org
Although sentences unfold sequentially, one word at a time, most linguistic theories propose
that their underlying syntactic structure involves a tree of nested phrases rather than a linear …

Neuronal connected burst cascades bridge macroscale adaptive signatures across arousal states

BR Munn, EJ Müller, V Medel, SL Naismith… - Nature …, 2023 - nature.com
The human brain displays a rich repertoire of states that emerge from the microscopic
interactions of cortical and subcortical neurons. Difficulties inherent within large-scale …

Multimodal modeling of neural network activity: computing LFP, ECoG, EEG, and MEG signals with LFPy 2.0

E Hagen, S Næss, TV Ness… - Frontiers in …, 2018 - frontiersin.org
Recordings of extracellular electrical, and later also magnetic, brain signals have been the
dominant technique for measuring brain activity for decades. The interpretation of such …

Local field potentials primarily reflect inhibitory neuron activity in human and monkey cortex

B Teleńczuk, N Dehghani, M Le Van Quyen, SS Cash… - Scientific reports, 2017 - nature.com
The local field potential (LFP) is generated by large populations of neurons, but unitary
contribution of spiking neurons to LFP is not well characterised. We investigated this …

CoreNEURON: an optimized compute engine for the NEURON simulator

P Kumbhar, M Hines, J Fouriaux… - Frontiers in …, 2019 - frontiersin.org
The NEURON simulator has been developed over the past three decades and is widely
used by neuroscientists to model the electrical activity of neuronal networks. Large network …

Uncovering circuit mechanisms of current sinks and sources with biophysical simulations of primary visual cortex

AE Rimehaug, AJ Stasik, E Hagen, YN Billeh… - elife, 2023 - elifesciences.org
Local field potential (LFP) recordings reflect the dynamics of the current source density
(CSD) in brain tissue. The synaptic, cellular, and circuit contributions to current sinks and …