Molecular farming–the slope of enlightenment

R Fischer, JF Buyel - Biotechnology advances, 2020 - Elsevier
Molecular farming can be defined as the use of plants to produce recombinant protein
products. The technology is now> 30 years old. The early promise of molecular farming was …

Plants as sources of natural and recombinant anti-cancer agents

JF Buyel - Biotechnology advances, 2018 - Elsevier
Herbal remedies were the first medicines used by humans due to the many
pharmacologically active secondary metabolites produced by plants. Some of these …

[HTML][HTML] Plants as factories for human pharmaceuticals: applications and challenges

J Yao, Y Weng, A Dickey, KY Wang - International journal of molecular …, 2015 - mdpi.com
Plant molecular farming (PMF), defined as the practice of using plants to produce human
therapeutic proteins, has received worldwide interest. PMF has grown and advanced …

Recent advances towards development and commercialization of plant cell culture processes for the synthesis of biomolecules

SA Wilson, SC Roberts - Plant biotechnology journal, 2012 - Wiley Online Library
Plant cell culture systems were initially explored for use in commercial synthesis of several
high‐value secondary metabolites, allowing for sustainable production that was not limited …

Plant molecular farming–integration and exploitation of side streams to achieve sustainable biomanufacturing

JF Buyel - Frontiers in plant science, 2019 - frontiersin.org
Plants have unique advantages over other systems such as mammalian cells for the
production of valuable small molecules and proteins. The benefits cited most often include …

Plant molecular farming: much more than medicines

M Tschofen, D Knopp, E Hood… - Annual Review of …, 2016 - annualreviews.org
Plants have emerged as commercially relevant production systems for pharmaceutical and
nonpharmaceutical products. Currently, the commercially available nonpharmaceutical …

[HTML][HTML] On the verge of the market–Plant factories for the automated and standardized production of biopharmaceuticals

JW Huebbers, JF Buyel - Biotechnology Advances, 2021 - Elsevier
The market for biopharmaceuticals is dominated by recombinant proteins and is driven
mainly by the development of vaccines and antibodies. Manufacturing predominantly relies …

Extraction and downstream processing of plant-derived recombinant proteins

JF Buyel, RM Twyman, R Fischer - Biotechnology advances, 2015 - Elsevier
Plants offer the tantalizing prospect of low-cost automated manufacturing processes for
biopharmaceutical proteins, but several challenges must be addressed before such goals …

Challenges and opportunities in the purification of recombinant tagged proteins

AS Pina, CR Lowe, ACA Roque - Biotechnology advances, 2014 - Elsevier
The purification of recombinant proteins by affinity chromatography is one of the most
efficient strategies due to the high recovery yields and purity achieved. However, this is …

Commercial aspects of pharmaceutical protein production in plants

R Fischer, S Schillberg, JF Buyel… - Current …, 2013 - ingentaconnect.com
Many different plant-based systems have been used to produce recombinant
pharmaceutical proteins but only a small number have made the leap from an experimental …