Cells are the fundamental units of biological systems and exhibit unique development
trajectories and molecular features. Our exploration of how the genomes orchestrate the …

Single-cell RNA sequencing (scRNA-seq) has enabled researchers to study gene
expression at the cellular level. However, due to the extremely low levels of transcripts in a …

Overactivated inflammation and catabolism induced by proinflammatory macrophages are
involved in the pathological processes of intervertebral disc (IVD) degeneration (IVDD). Our …

With the advances in single-cell sequencing techniques, numerous analytical methods have
been developed for delineating cell development. However, most are based on Euclidean …

Dimension reduction tools preserving similarity and graph structure such as t-SNE and
UMAP can capture complex biological patterns in high-dimensional data. However, these …

Objective Rat intervertebral disc (IVD) is one of the most commonly used and cost-effective
alternative models for human IVD. Many IVD related clinical studies need to be pre-tested on …

Summary Single-cell" omics"-based measurements are often high dimensional so that
dimensionality reduction (DR) algorithms are necessary for data visualization and analysis …

Background Poor prognosis, resistance to chemotherapy, insensitivity to radiotherapy, and a
high prevalence of adverse drug reactions remain urgent issues for breast cancer (BC) …

Single-cell RNA sequencing reveals the gene structure and gene expression status of a
single cell, which can reflect the heterogeneity between cells. However, batch effects caused …

Single-cell RNA sequencing (scRNA-seq) can reveal accurate and sensitive RNA
abundance in a single sample, but robust integration of multiple samples remains …