BK virus nephropathy and kidney transplantation

DL Bohl, DC Brennan - Clinical Journal of the American Society of …, 2007 - journals.lww.com
Nephropathy from BK virus (BKV) infection is an evolving challenge in kidney transplant
recipients. It is the consequence of modern potent immunosuppression aimed at reducing …

Treatment of polyomavirus infection in kidney transplant recipients: a systematic review

O Johnston, D Jaswal, JS Gill, S Doucette… - …, 2010 - journals.lww.com
Background. Polyomavirus-associated nephropathy (PVAN) is an important cause of kidney
graft loss but there is no consensus on its management. This study aimed to systematically …

[HTML][HTML] Adjuvant low‐dose cidofovir therapy for BK polyomavirus interstitial nephritis in renal transplant recipients

DRJ Kuypers, AK Vandooren, E Lerut… - American journal of …, 2005 - Elsevier
BK virus interstitial nephritis (BKVIN) is a serious complication after kidney grafting,
necessitating drastic reduction of immunosuppressive therapy in order to enable viral …

[HTML][HTML] Kidney transplant function and histological clearance of virus following diagnosis of polyomavirus-associated nephropathy (PVAN)

HM Wadei, AD Rule, M Lewin, AS Mahale… - American Journal of …, 2006 - Elsevier
Polyomavirus-associated nephropathy (PVAN) is managed by reduced immunosuppression
with or without antiviral therapy. Data from 55 patients with biopsy-proven PVAN were …

Antivirals for the treatment of polyomavirus BK replication

CH Rinaldo, HH Hirsch - Expert review of anti-infective therapy, 2007 - Taylor & Francis
Antiviral drugs with specific activity against polyomavirus replication have not been
developed in the past. This deficiency has become fully apparent with the emergence of …

[HTML][HTML] A multivalent polyomavirus vaccine elicits durable neutralizing antibody responses in macaques

A Peretti, DG Scorpio, WP Kong, YYS Pang… - Vaccine, 2023 - Elsevier
Abstract In 2019, there were about 100,000 kidney transplants globally, with more than a
quarter of them performed in the United States. Unfortunately, some engrafted organs are …

BK virus nephropathy: prevalence, impact and management strategies

R Sharma, M Zachariah - International Journal of Nephrology and …, 2020 - Taylor & Francis
BK virus reactivation as a result of therapeutic immunosuppression following renal
transplant can result in BK polyomavirus nephropathy and renal allograft loss. This is a …

Observations on the use of cidofovir for BK virus infection in renal transplantation

SA Kuten, SJ Patel, RJ Knight… - Transplant Infectious …, 2014 - Wiley Online Library
Background In renal transplantation, BK virus infection can result in significant graft
nephropathy and loss. While reduction in immunosuppression (IS) is considered standard …

Why hasn't eliminating acute rejection improved graft survival?

JR Tantravahi, KL Womer, B Kaplan - Annu. Rev. Med., 2007 - annualreviews.org
Although patients with end-stage renal disease can be maintained with dialysis therapy, the
superiority of patient survival with renal transplantation makes transplantation the preferred …

Polyomavirus‐associated nephropathy: update of clinical management in kidney transplant patients

J Trofe, HH Hirsch, E Ramos - Transplant infectious disease, 2006 - Wiley Online Library
Over the last decade, polyomavirus‐associated nephropathy (PVAN) has occurred with
increasing frequency after renal transplantation, leading to significant renal dysfunction and …