Vagal sensory neurons constitute the major afferent supply to the airways and lungs.
Subsets of afferents are defined by their embryological origin, molecular profile …

Astrocytes are no longer seen as a homogenous population of cells. In fact, recent studies
indicate that astrocytes are morphologically and functionally diverse and play critical roles in …

The formation of functional neural circuits in the vertebrate central nervous system (CNS)
requires that appropriate numbers of the correct types of neuronal and glial cells are …

In the mammalian pancreas, the endocrine cell types of the islets of Langerhans, including
the α-, β-, δ-, and pancreatic polypeptide cells as well as the exocrine cells, derive from …

Certain morphological, physiological and molecular characteristics are shared by all
neurons. However, despite these similarities, neurons constitute the most diverse cell …

The pancreas contains both exocrine and endocrine cells, but the molecular mechanisms
controlling the differentiation of these cell types are largely unknown. Despite their …

The sympathetic, parasympathetic and enteric ganglia are the main components of the
peripheral autonomic nervous system, and are all derived from the neural crest. The factors …

The generation of neurons from stem cells involves the activity of proneural basic helix-loop-
helix (bHLH) proteins, but the mechanism by which these proteins irreversibly commit stem …

While the transmembrane protein Notch plays an important role in various aspects of
development, and diseases including tumors and neurological disorders, the intracellular …

Basic helix–loop–helix (bHLH) transcription factors have been identified for neurons and
their precursors but not for glial cells. We have identified two bHLH factors, Oligo1 and …