ABSTRACT RNA interference (RNAi) provides researchers with a versatile means to
modulate target gene expression. The major forms of RNAi molecules, genome-derived …

Recent medical advances have exploited the ability to address a given disease at the
underlying level of transcription and translation. These treatment paradigms utilize nucleic …

As a type of short noncoding RNAs, microRNA (miRNA) undoubtedly plays a crucial role in
cancer development. Since the discovery of the identity and clinical functions of miRNAs …

Traditional Chinese medicine (TCM) has been practiced for thousands of years and at the
present time is widely accepted as an alternative treatment for cancer. In this review, we …

Clustered regulatory interspaced short palindromic repeats (CRISPR) has changed
biomedical research and provided entirely new models to analyze every aspect of …

The first therapeutic nucleic acid, a DNA oligonucleotide, was approved for clinical use in
1998. Twenty years later, in 2018, the first therapeutic RNA-based oligonucleotide was …

In just over two decades since the discovery of the first microRNA (miRNA), the field of
miRNA biology has expanded considerably. Insights into the roles of miRNAs in …

Recent advances have begun to clarify the physiological and pathological roles of non-
coding RNAs (ncRNAs) in various diseases, including cancer. Among these, microRNAs …

Glioblastoma multiforme (GBM) is the most common, malignant, poorly promising primary
brain tumor. GBM is characterized by an infiltrating growth nature, abundant vascularization …

The discovery of miRNAs in the mid-90s has changed the dogma of gene expression
regulation. Currently, miRNAs are the main theme of thousands of publications each year …