Our sense of touch emerges from an array of mechanosensory structures residing within the
fabric of our skin. These tactile end organ structures convert innocuous forces acting on the …

Primary somatosensory neurons convey salient information about our external environment
and internal state to the CNS, allowing us to detect, perceive, and react to a wide range of …

Somatosensory autonomic reflexes allow electroacupuncture stimulation (ES) to modulate
body physiology at distant sites,,,,–(for example, suppressing severe systemic inflammation …

Classical migraine patients experience aura, which is transient neurological deficits
associated with cortical spreading depression (CSD), preceding headache attacks. It is not …

The versatility of somatosensation arises from heterogeneous dorsal root ganglion (DRG)
neurons. However, soma transcriptomes of individual human (h) DRG neurons—critical …

Tissue injury and inflammation markedly alter touch perception, making normally innocuous
sensations become intensely painful. Although this sensory distortion, known as tactile …

Across mammalian skin, structurally complex and diverse mechanosensory end organs
respond to mechanical stimuli and enable our perception of dynamic, light touch. How forces …

Despite the potential importance of genital mechanosensation for sexual reproduction, little
is known about how perineal touch influences mating. We explored how mechanosensation …

The properties of dorsal root ganglia (DRG) neurons that innervate the distal colon are
poorly defined, hindering our understanding of their roles in normal physiology and …

The gastrointestinal tract is in a state of constant motion. These movements are tightly
regulated by the presence of food and help digestion by mechanically breaking down and …