Viroporins are small, hydrophobic proteins that are encoded by a wide range of clinically
relevant animal viruses. When these proteins oligomerize in host cell membranes, they form …

Viral protein U (Vpu) is a type 1 membrane-associated accessory protein that is unique to
human immunodeficiency virus type 1 (HIV-1) and a subset of related simian …

The three-dimensional structure of the channel-forming trans-membrane domain of virus
protein “u”(Vpu) of HIV-1 was determined by NMR spectroscopy in micelle and bilayer …

We report molecular dynamics simulations of a generic hydrophobic nanopore connecting
two reservoirs which are initially at different Na+ concentrations, as in a biological cell. The …

HIV accessory genes are expressed throughout the viral life cycle and regulate wide-
ranging aspects of virus replication including viral infectivity (Vif and Nef), viral gene …

α-Helical membrane proteins fulfill many vital roles in all living cells and constitute the
majority of drug targets. However, their relevance is in no way paralleled by our current …

Pathogenic microorganisms encode proteins that antagonize specific aspects of innate or
adaptive immunity. Just as the study of the HIV-1 accessory protein Vif led to the …

A coarse-grain model for amphiphilic diblock copolymers is developed by fitting the required
parameters to properties taken from all-atom molecular dynamics simulations and …

Abstract HIV‐1 Vpu is an 81‐residue protein with a single N‐terminal transmembrane (TM)
helical segment that is involved in the release of new virions from host cell membranes. Vpu …

Highlights•Viral protein simulations are among the largest all-atom simulations ever
published.•All-atom simulations reveal the dynamics of viral proteins at chemical …