This review is focused on purinergic neurotransmission, ie, ATP released from nerves as a
transmitter or cotransmitter to act as an extracellular signaling molecule on both pre-and …

Purpose: This review is intended to bring to the informed reader the current state of
knowledge about meibomian lipids and the art for analyzing them. Methods: At the forefront …

Dry eye disease (DED) is a multifactorial syndrome that can be caused by alteration in the
quality or quantity of the precorneal tear film. It is considered one of the most common ocular …

Wound healing and cancer metastasis share a common starting point, namely, a change in
the phenotype of some cells from stationary to motile. The term, epithelial-to-mesenchymal …

Recent advances in the understanding of dry eye disease (DED) have revealed previously
unexplored targets for drug therapy. One of these drugs is diquafosol, a uridine nucleotide …

Purpose: To compare signs and symptoms of dry eye in keratoconus (KC) patients versus
healthy subjects. Methods: A total of 15 KC patients (KC group, n= 15 eyes) and 16 healthy …

Injury to epithelial cells results in the release of ATP and stimulation of purinergic receptors
and is thought to alter cell migration and wound repair. Medium from the injured cells …

Diquafosol is known as a purinergic P2Y2 receptor (P2Y2R) agonist that stimulates water
and mucin secretion from conjunctival epithelial cells and goblet cells, leading to tear film …

Agonists and antagonists of various subtypes of G protein coupled adenosine receptors
(ARs), P2Y receptors (P2YRs), and ATP-gated P2X receptor ion channels (P2XRs) are …

purpose. Previously, the authors demonstrated that BzATP, a P2X 7 receptor agonist,
enhanced corneal epithelial migration in vitro. The goal here was to characterize the role of …