Map** spatially resolved transcriptomes in human and mouse pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with poor prognosis and
limited treatment options. Efforts to identify effective treatments are thwarted by limited …
limited treatment options. Efforts to identify effective treatments are thwarted by limited …
Comparison of spatial transcriptomics technologies across six cancer types
Spatial biology experiments integrate the molecular and histological landscape of tissues to
provide a previously inaccessible view of tissue biology, unlocking the architecture of …
provide a previously inaccessible view of tissue biology, unlocking the architecture of …
Spatial dynamics of the develo** human heart
Heart development relies on a topologically defined interplay between a diverse array of
cardiac cells. We finely curated spatial and single-cell measurements with subcellular …
cardiac cells. We finely curated spatial and single-cell measurements with subcellular …
[PDF][PDF] Spatial transcriptomics in breast cancer reveals tumour microenvironment-driven drug responses and clonal therapeutic heterogeneity
MJ Jiménez-Santos, S García-Martín… - NAR …, 2024 - academic.oup.com
Breast cancer patients are categorized into three subtypes with distinct treatment
approaches. Precision oncology has increased patient outcomes by targeting the specific …
approaches. Precision oncology has increased patient outcomes by targeting the specific …
[HTML][HTML] EBF1-COX4I2 signaling axis promotes a myofibroblast-like phenotype in cancer-associated fibroblasts (CAFs) and is associated with an immunosuppressive …
J Li, Y Liu, S Wang, Z Lu, Q Ye, J Zhou, X Zou… - International …, 2024 - Elsevier
Immunotherapy has limited response rates in colorectal cancer (CRC) due to an
immunosuppressive tumor microenvironment (TME). Combining transcriptome sequencing …
immunosuppressive tumor microenvironment (TME). Combining transcriptome sequencing …
Standalone single-and bi-layered human skin 3D models supported by recombinant silk feature native spatial organization
Physiologically relevant human skin models that include key skin cell types can be used for
in vitro drug testing, skin pathology studies, or clinical applications such as skin grafts …
in vitro drug testing, skin pathology studies, or clinical applications such as skin grafts …
A pan-cancer single-cell transcriptional analysis of antigen-presenting cancer-associated fibroblasts in the tumor microenvironment
J Chen, R Chen, J Huang - Frontiers in Immunology, 2024 - frontiersin.org
Background Cancer-associated fibroblasts (CAFs) are the primary stromal cells found in
tumor microenvironment, and display high plasticity and heterogeneity. By using single-cell …
tumor microenvironment, and display high plasticity and heterogeneity. By using single-cell …
Single-cell and spatial transcriptomics analysis of human adrenal aging
N Iwahashi, H Umakoshi, M Fujita, T Fukumoto… - Molecular …, 2024 - Elsevier
Objective The human adrenal cortex comprises three functionally and structurally distinct
layers that produce layer-specific steroid hormones. With aging, the human adrenal cortex …
layers that produce layer-specific steroid hormones. With aging, the human adrenal cortex …
Gene expression of single cells mapped in tissue sections
PL Ståhl - 2024 - nature.com
Gene expression of single cells mapped in tissue sections Skip to main content Thank you for
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Scalable image-based visualization and alignment of spatial transcriptomics datasets
We present STIM, an imaging-based computational framework focused on visualizing and
aligning high-throughput spatial sequencing datasets. STIM is built on the powerful, scalable …
aligning high-throughput spatial sequencing datasets. STIM is built on the powerful, scalable …