X-linked hypophosphataemia (XLH) is a rare metabolic bone disorder caused by pathogenic
variants in the PHEX gene, which is predominantly expressed in osteoblasts, osteocytes and …

Phenylketonuria (PKU) is an autosomal recessive inborn error of phenylalanine metabolism
caused by deficiency in the enzyme phenylalanine hydroxylase that converts phenylalanine …

Abstract Lifestyle choices influence 20–40% of adult peak bone mass. Therefore,
optimization of lifestyle factors known to influence peak bone mass and strength is an …

Abstract Cosponsoring Associations: The American Society for Reproductive Medicine, the
European Society of Endocrinology, and the Pediatric Endocrine Society. This guideline was …

Background Nutritional status is paramount in Cystic Fibrosis (CF) and is directly correlated
with morbidity and mortality. The first ESPEN-ESPGHAN-ECFS guidelines on nutrition care …

Purpose Functional hypothalamic amenorrhea secondary to low weight, excessive exercise,
and/or high levels of stress is common among young women. Adolescence is a time in …

Dual-energy X-ray absorptiometry (DXA) is a technology that is widely used to diagnose
osteoporosis, assess fracture risk, and monitor changes in bone mineral density (BMD). The …

Osteoporosis is associated with increased fragility of bone and a subsequent increased risk
of fracture. The diagnosis of osteoporosis is intimately linked with the imaging and …

Clinical evidence indicates a close association between muscle dysfunction and bone loss;
however, the underlying mechanisms remain unclear. Here, we report that muscle …

Background Maternal vitamin D status has been associated with bone mass of offspring in
many, but not all, observational studies. However, maternal vitamin D repletion during …