In the last decade the impressive expansion of our knowledge of the vast microbial
community that resides in the human intestine, the gut microbiota, has provided support to …

Visceral pain is a global term used to describe pain originating from the internal organs of
the body, which affects a significant proportion of the population and is a common feature of …

Functional gastrointestinal disorders (FGIDs) are characterized by chronic complaints
arising from disorganized brain-gut interactions leading to dysmotility and hypersensitivity …

The pathogenesis of irritable bowel syndrome (IBS), once thought to be largely psychogenic
in origin, is now understood to be multifactorial. One of the reasons for this paradigm shift is …

Abnormalities of mast cell structure or function may play prominent roles in irritable bowel
syndrome (IBS) symptom genesis. Mast cells show close apposition to sensory nerves and …

Irritable bowel syndrome (IBS) is a common gastrointestinal disorder marked by chronic
abdominal pain, bloating, and irregular bowel habits. Effective treatments are still actively …

Visceral pain is a global term used to describe pain originating from the internal organs,
which is distinct from somatic pain. It is a hallmark of functional gastrointestinal disorders …

CD4 T helper (Th) cell differentiation into distinct T cell subsets is critical to the normal
function of the immune system. Until recently, the paradigm held that naïve T cells …

Liver cirrhosis is a paradigm of intestinal dysbiosis. The qualitative and quantitative
derangement of intestinal microbial community reported in cirrhotic patients seems to be …

Methods We prospectively enrolled patients with refractory FGID based on Rome III criteria.
A glucose hydrogen breath test (GHBT) was performed using a gas analyzer after an …