Pancreatic cancer: Advances and challenges
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers. Significant
efforts have largely defined major genetic factors driving PDAC pathogenesis and …
efforts have largely defined major genetic factors driving PDAC pathogenesis and …
Cancer cell plasticity during tumor progression, metastasis and response to therapy
A Pérez-González, K Bévant, C Blanpain - Nature cancer, 2023 - nature.com
Cell plasticity represents the ability of cells to be reprogrammed and to change their fate and
identity, enabling homeostasis restoration and tissue regeneration following damage. Cell …
identity, enabling homeostasis restoration and tissue regeneration following damage. Cell …
Hallmarks of cancer: new dimensions
D Hanahan - Cancer discovery, 2022 - AACR
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast complexity
of cancer phenotypes and genotypes into a provisional set of underlying principles. As …
of cancer phenotypes and genotypes into a provisional set of underlying principles. As …
Pancreatic cancer evolution and heterogeneity: integrating omics and clinical data
Pancreatic ductal adenocarcinoma (PDAC), already among the deadliest epithelial
malignancies, is rising in both incidence and contribution to overall cancer deaths. Decades …
malignancies, is rising in both incidence and contribution to overall cancer deaths. Decades …
Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer
Pancreatic ductal adenocarcinoma is a lethal disease with limited treatment options and
poor survival. We studied 83 spatial samples from 31 patients (11 treatment-naïve and 20 …
poor survival. We studied 83 spatial samples from 31 patients (11 treatment-naïve and 20 …
Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis
INTRODUCTION The association between tumors and inflammation is a long-established
clinical observation. Although many studies have demonstrated that the inflammatory …
clinical observation. Although many studies have demonstrated that the inflammatory …
Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma
J Peng, BF Sun, CY Chen, JY Zhou, YS Chen, H Chen… - Cell research, 2019 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer
featured with high intra-tumoral heterogeneity and poor prognosis. To comprehensively …
featured with high intra-tumoral heterogeneity and poor prognosis. To comprehensively …
Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis
The response to tumor-initiating inflammatory and genetic insults can vary among
morphologically indistinguishable cells, suggesting as yet uncharacterized roles for …
morphologically indistinguishable cells, suggesting as yet uncharacterized roles for …
Molecular subtypes of pancreatic cancer
Cancers that appear morphologically similar often have dramatically different clinical
features, respond variably to therapy and have a range of outcomes. Compelling evidence …
features, respond variably to therapy and have a range of outcomes. Compelling evidence …
Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches
Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with poor
prognosis and rising incidence. Late detection and a particularly aggressive biology are the …
prognosis and rising incidence. Late detection and a particularly aggressive biology are the …