Pancreatic cancer: Advances and challenges

CJ Halbrook, CA Lyssiotis, MP di Magliano, A Maitra - Cell, 2023 - cell.com
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers. Significant
efforts have largely defined major genetic factors driving PDAC pathogenesis and …

Cancer cell plasticity during tumor progression, metastasis and response to therapy

A Pérez-González, K Bévant, C Blanpain - Nature cancer, 2023 - nature.com
Cell plasticity represents the ability of cells to be reprogrammed and to change their fate and
identity, enabling homeostasis restoration and tissue regeneration following damage. Cell …

Hallmarks of cancer: new dimensions

D Hanahan - Cancer discovery, 2022 - AACR
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast complexity
of cancer phenotypes and genotypes into a provisional set of underlying principles. As …

Pancreatic cancer evolution and heterogeneity: integrating omics and clinical data

AA Connor, S Gallinger - Nature Reviews Cancer, 2022 - nature.com
Pancreatic ductal adenocarcinoma (PDAC), already among the deadliest epithelial
malignancies, is rising in both incidence and contribution to overall cancer deaths. Decades …

Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer

D Cui Zhou, RG Jayasinghe, S Chen, JM Herndon… - Nature …, 2022 - nature.com
Pancreatic ductal adenocarcinoma is a lethal disease with limited treatment options and
poor survival. We studied 83 spatial samples from 31 patients (11 treatment-naïve and 20 …

Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis

E Del Poggetto, IL Ho, C Balestrieri, EY Yen, S Zhang… - Science, 2021 - science.org
INTRODUCTION The association between tumors and inflammation is a long-established
clinical observation. Although many studies have demonstrated that the inflammatory …

Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma

J Peng, BF Sun, CY Chen, JY Zhou, YS Chen, H Chen… - Cell research, 2019 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer
featured with high intra-tumoral heterogeneity and poor prognosis. To comprehensively …

Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis

C Burdziak, D Alonso-Curbelo, T Walle, J Reyes… - Science, 2023 - science.org
The response to tumor-initiating inflammatory and genetic insults can vary among
morphologically indistinguishable cells, suggesting as yet uncharacterized roles for …

Molecular subtypes of pancreatic cancer

EA Collisson, P Bailey, DK Chang… - Nature reviews …, 2019 - nature.com
Cancers that appear morphologically similar often have dramatically different clinical
features, respond variably to therapy and have a range of outcomes. Compelling evidence …

Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches

M Orth, P Metzger, S Gerum, J Mayerle, G Schneider… - Radiation …, 2019 - Springer
Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with poor
prognosis and rising incidence. Late detection and a particularly aggressive biology are the …