The genetic information of human cells is stored in the context of chromatin, which is
subjected to DNA methylation and various histone modifications. Such a 'language'of …

Cancer was thought to be caused solely by genetic mutations in oncogenes and tumor
suppressor genes. In the last 35 years, however, epigenetic changes have been …

With the introduction of large-scale molecular profiling methods and high-throughput
sequencing technologies, the genomic features of most lymphoid neoplasms have been …

The activities of non-haematopoietic cells (NHCs), including mesenchymal stromal cells and
endothelial cells, in lymphomas are reported to underlie lymphomagenesis. However, our …

Cells remember their identities, in part, by using epigenetic marks—chemical modifications
placed along the genome. How can mark patterns remain stable over cell generations …

Angioimmunoblastic T cell lymphoma (AITL) is a peripheral T cell lymphoma that originates
from T follicular helper (Tfh) cells and exhibits a prominent tumor microenvironment (TME) …

Simple Summary Diffuse large B-cell lymphoma (DLBCL) is the most common type of
malignant lymphoid neoplasm and includes morphologically and molecularly …

Trimethylated histone H3 lysine 27 (H3K27me3) regulates gene repression, cell-fate
determination and differentiation. We report that a conserved bromo-adjacent homology …

Targeted therapies have come to play an increasingly important role in cancer therapy over
the past two decades. This success has been made possible in large part by technological …

Background Individualization of treatment in Hodgkin's lymphoma is necessary to improve
cure rates and reduce treatment side effects. Currently, it is hindered by a lack of genomic …