The members of the Tear Film Subcommittee reviewed the role of the tear film in dry eye
disease (DED). The Subcommittee reviewed biophysical and biochemical aspects of tears …

In 1929 Drury and Szent-Györgyi published a seminal paper describing the potent actions of
adenine compounds. Some decades later, adenosine 5'-triphosphate (ATP) was proposed …

The thin layer of tears covering the ocular surface are a complex body fluid containing
thousands of molecules of varied form and function of several origins. In this review, we …

Abstract Recently, the oxidoreductase, glyceraldehyde-3-phosphate dehydrogenase
(GAPDH), has become a subject of interest as more and more studies reveal a surfeit of …

Dry eye disease (DED) is a multifactorial syndrome that can be caused by alteration in the
quality or quantity of the precorneal tear film. It is considered one of the most common ocular …

The tear film overlying the epithelial cells of the eye's surface is vital to visual function, and
its composition is reflective of ocular surface health. The ultrasmall volume of tears poses …

Abstract P2Y receptors (P2YRs) are a family of G protein-coupled receptors activated by
extracellular nucleotides. Physiological P2YR agonists include purine and pyrimidine …

Recent advances in the understanding of dry eye disease (DED) have revealed previously
unexplored targets for drug therapy. One of these drugs is diquafosol, a uridine nucleotide …

The purpose of the present study was to understand the mechanisms of action of diquafosol,
a stable derivative of uridine 5′-triphosphate, on Cl–transport across the isolated rabbit …

Dinucleoside polyphosphates act as agonists on purinergic P2Y receptors to mediate a
variety of cellular processes. Symmetrical, naturally occurring purine dinucleotides are found …