Sequencing pools of individuals—mining genome-wide polymorphism data without big funding
The analysis of polymorphism data is becoming increasingly important as a complementary
tool to classical genetic analyses. Nevertheless, despite plunging sequencing costs …
tool to classical genetic analyses. Nevertheless, despite plunging sequencing costs …
Genomics and the origin of species
Speciation is a fundamental evolutionary process, the knowledge of which is crucial for
understanding the origins of biodiversity. Genomic approaches are an increasingly …
understanding the origins of biodiversity. Genomic approaches are an increasingly …
Genetics on the Fly: A Primer on the Drosophila Model System
Fruit flies of the genus Drosophila have been an attractive and effective genetic model
organism since Thomas Hunt Morgan and colleagues made seminal discoveries with them …
organism since Thomas Hunt Morgan and colleagues made seminal discoveries with them …
Using next-generation sequencing to isolate mutant genes from forward genetic screens
K Schneeberger - Nature Reviews Genetics, 2014 - nature.com
The long-lasting success of forward genetic screens relies on the simple molecular basis of
the characterized phenotypes, which are typically caused by mutations in single genes …
the characterized phenotypes, which are typically caused by mutations in single genes …
Highly Contiguous Genome Assemblies of 15 Drosophila Species Generated Using Nanopore Sequencing
The Drosophila genus is a unique group containing a wide range of species that occupy
diverse ecosystems. In addition to the most widely studied species, Drosophila …
diverse ecosystems. In addition to the most widely studied species, Drosophila …
Rapid evolutionary turnover underlies conserved lncRNA–genome interactions
Many long noncoding RNAs (lncRNAs) can regulate chromatin states, but the evolutionary
origin and dynamics driving lncRNA–genome interactions are unclear. We adapted an …
origin and dynamics driving lncRNA–genome interactions are unclear. We adapted an …
Molecular population genetics
Molecular population genetics aims to explain genetic variation and molecular evolution
from population genetics principles. The field was born 50 years ago with the first measures …
from population genetics principles. The field was born 50 years ago with the first measures …
Satellite DNA-mediated diversification of a sex-ratio meiotic drive gene family in Drosophila
CA Muirhead, DC Presgraves - Nature Ecology & Evolution, 2021 - nature.com
Sex chromosomes are susceptible to the evolution of selfish meiotic drive elements that bias
transmission and distort progeny sex ratios. Conflict between such sex-ratio drivers and the …
transmission and distort progeny sex ratios. Conflict between such sex-ratio drivers and the …
Population genomics from pool sequencing
Next generation sequencing of pooled samples is an effective approach for studies of
variability and differentiation in populations. In this paper we provide a comprehensive set of …
variability and differentiation in populations. In this paper we provide a comprehensive set of …
[HTML][HTML] Non-random DNA fragmentation in next-generation sequencing
Abstract Next Generation Sequencing (NGS) technology is based on cutting DNA into small
fragments and their massive parallel sequencing. The multiple overlap** segments …
fragments and their massive parallel sequencing. The multiple overlap** segments …