Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy

M Gao, F Yu, C Lv, J Choo, L Chen - Chemical Society Reviews, 2017 - pubs.rsc.org
Surgical resection of solid tumors is currently the gold standard and preferred therapeutic
strategy for cancer. Chemotherapy drugs also make a significant contribution by inhibiting …

Structural modification strategies for the rational design of red/NIR region BODIPYs

H Lu, J Mack, Y Yang, Z Shen - Chemical Society Reviews, 2014 - pubs.rsc.org
This review focuses on classifying different types of long wavelength absorbing BODIPY
dyes based on the wide range of structural modification methods that have been adopted …

Molecular imaging of the tumor microenvironment

Z Zhou, ZR Lu - Advanced Drug Delivery Reviews, 2017 - Elsevier
The tumor microenvironment plays a critical role in tumor initiation, progression, metastasis,
and resistance to therapy. It is different from normal tissue in the extracellular matrix …

Fluorescence imaging in vivo: recent advances

J Rao, A Dragulescu-Andrasi, H Yao - Current opinion in biotechnology, 2007 - Elsevier
In vivo fluorescence imaging uses a sensitive camera to detect fluorescence emission from
fluorophores in whole-body living small animals. To overcome the photon attenuation in …

Peptide-based imaging agents for cancer detection

X Sun, Y Li, T Liu, Z Li, X Zhang, X Chen - Advanced drug delivery reviews, 2017 - Elsevier
Selective receptor-targeting peptide based agents have attracted considerable attention in
molecular imaging of tumor cells that overexpress corresponding peptide receptors due to …

Nucleolin-targeting liposomes guided by aptamer AS1411 for the delivery of siRNA for the treatment of malignant melanomas

L Li, J Hou, X Liu, Y Guo, Y Wu, L Zhang, Z Yang - Biomaterials, 2014 - Elsevier
BRAF gene mutation is found in more than 60% of malignant melanomas, which are difficult
to treat. In this study, a new tumor-targeting liposome was developed to deliver anti-BRAF …

The complex role of multivalency in nanoparticles targeting the transferrin receptor for cancer therapies

J Wang, S Tian, RA Petros, ME Napier… - Journal of the …, 2010 - ACS Publications
Transferrin receptor (TfR, CD71) has long been a therapeutic target due to its
overexpression in many malignant tissues. In this study, PRINT nanoparticles were …

Nanovehicular intracellular delivery systems

A Prokop, JM Davidson - Journal of pharmaceutical sciences, 2008 - Elsevier
This article provides an overview of principles and barriers relevant to intracellular drug and
gene transport, accumulation and retention (collectively called as drug delivery) by means of …

Ultrasmall near-infrared gold nanoclusters for tumor fluorescence imaging in vivo

X Wu, X He, K Wang, C **e, B Zhou, Z Qing - Nanoscale, 2010 - pubs.rsc.org
In this paper, we explore the possibility of using ultrasmall near-infrared (NIR) gold
nanoclusters (AuNCs) as novel contrast imaging agents for tumor fluorescence imaging in …

Peptide-based probes for targeted molecular imaging

S Lee, J **e, X Chen - Biochemistry, 2010 - ACS Publications
Targeted molecular imaging techniques have become indispensable tools in modern
diagnostics because they provide accurate and specific diagnosis of disease information …