Recent progress in broadly neutralizing antibodies to HIV
D Sok, DR Burton - Nature immunology, 2018 - nature.com
In this Review, we highlight some recent developments in the discovery and application of
broadly neutralizing antibodies (bnAbs) to human immunodeficiency virus (HIV); ie …
broadly neutralizing antibodies (bnAbs) to human immunodeficiency virus (HIV); ie …
HIV-1 vaccines based on antibody identification, B cell ontogeny, and epitope structure
PD Kwong, JR Mascola - Immunity, 2018 - cell.com
HIV-1 vaccine development has been stymied by an inability to induce broadly reactive
neutralizing antibodies to the envelope (Env) trimer, the sole viral antigen on the virion …
neutralizing antibodies to the envelope (Env) trimer, the sole viral antigen on the virion …
Antiretroviral drugs for treatment and prevention of HIV infection in adults: 2018 recommendations of the International Antiviral Society–USA Panel
MS Saag, CA Benson, RT Gandhi, JF Hoy… - Jama, 2018 - jamanetwork.com
Importance Antiretroviral therapy (ART) is the cornerstone of prevention and management of
HIV infection. Objective To evaluate new data and treatments and incorporate this …
HIV infection. Objective To evaluate new data and treatments and incorporate this …
[HTML][HTML] Multifaceted effects of antigen valency on B cell response composition and differentiation in vivo
How antigen valency affects B cells in vivo during immune responses is not well understood.
Here, using HIV immunogens with defined valencies ranging from 1 to 60, we investigated …
Here, using HIV immunogens with defined valencies ranging from 1 to 60, we investigated …
[HTML][HTML] Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance
KM Cirelli, DG Carnathan, B Nogal, JT Martin… - Cell, 2019 - cell.com
Conventional immunization strategies will likely be insufficient for the development of a
broadly neutralizing antibody (bnAb) vaccine for HIV or other difficult pathogens because of …
broadly neutralizing antibody (bnAb) vaccine for HIV or other difficult pathogens because of …
Precursor frequency and affinity determine B cell competitive fitness in germinal centers, tested with germline-targeting HIV vaccine immunogens
How precursor frequencies and antigen affinities impact interclonal B cell competition is a
particularly relevant issue for candidate germline-targeting HIV vaccine designs because of …
particularly relevant issue for candidate germline-targeting HIV vaccine designs because of …
Covalent organic frameworks for biomedical applications
Covalent organic frameworks (COFs) are porous organic polymeric materials that are
composed of organic elements and linked together by the thermodynamically stable …
composed of organic elements and linked together by the thermodynamically stable …
Passive immunotherapy of viral infections:'super-antibodies' enter the fray
LM Walker, DR Burton - Nature Reviews Immunology, 2018 - nature.com
Antibodies have been used for more than 100 years in the therapy of infectious diseases,
but a new generation of highly potent and/or broadly cross-reactive human monoclonal …
but a new generation of highly potent and/or broadly cross-reactive human monoclonal …
Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic
M Caskey, F Klein, MC Nussenzweig - Nature medicine, 2019 - nature.com
Combination anti-retroviral therapy (ART) has revolutionized the treatment and prevention of
HIV-1 infection. Taken daily, ART prevents and suppresses the infection. However, ART …
HIV-1 infection. Taken daily, ART prevents and suppresses the infection. However, ART …
Germline-targeting HIV vaccination induces neutralizing antibodies to the CD4 binding site
Eliciting potent and broadly neutralizing antibodies (bnAbs) is a major goal in HIV-1 vaccine
development. Here, we describe how germline-targeting immunogen BG505 SOSIP …
development. Here, we describe how germline-targeting immunogen BG505 SOSIP …