Antimicrobial peptides (AMPs) are distributed across all kingdoms of life and are an
indispensable component of host defenses. They consist of predominantly short cationic …

Antibiotic resistance is a major global health challenge and, worryingly, several key Gram
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …

With the rising incidences of antimicrobial resistance (AMR) and the diminishing options of
novel antimicrobial agents, it is paramount to decipher the molecular mechanisms of action …

The phosphoethanolamine transferase EptA utilizes phosphatidylethanolamine (PE) in the
bacterial cell membrane to modify the structure of lipopolysaccharide, thereby conferring …

The emergence of antibiotic resistance in bacteria is a major public-health issue. Synthesis
of efficient antibiotic-free material is very important for fighting bacterial infection-related …

The rapid dissemination of antibiotic resistance by horizontal gene transfer (HGT) renders
the global resistance crisis more tense and urgent as few effective antimicrobials are …

A significant increase in life-threatening infections caused by Gram-negative “superbugs” is
a serious threat to global health. With a dearth of new antibiotics in the developmental …

Polymyxins are increasingly used as the last-line therapeutic option for the treatment of
infections caused by multidrug-resistant Gram-negative bacteria. However, efforts to address …

Background MDR bacteria represent an urgent threat to human health globally. Polymyxins
are a last-line therapy against life-threatening Gram-negative 'superbugs', including …

Bacterial infections of the wound surface can be painful for patients, and traditional
dressings do not effectively address this problem. In this study, an antimicrobial wound …