Scorpion toxin peptide action at the ion channel subunit level
This review categorizes functionally validated actions of defined scorpion toxin (SCTX)
neuropeptides across ion channel subclasses, highlighting key trends in this rapidly …
neuropeptides across ion channel subclasses, highlighting key trends in this rapidly …
Venom-derived peptide modulators of cation-selective channels: friend, foe or frenemy
S Bajaj, J Han - Frontiers in pharmacology, 2019 - frontiersin.org
Ion channels play a key role in our body to regulate homeostasis and conduct electrical
signals. With the help of advances in structural biology, as well as the discovery of numerous …
signals. With the help of advances in structural biology, as well as the discovery of numerous …
Characterization and chemical synthesis of Cm39 (α-KTx 4.8): a scorpion toxin that inhibits voltage-gated K+ channel KV1. 2 and small-and intermediate-conductance …
MU Naseem, G Gurrola-Briones, MR Romero-Imbachi… - Toxins, 2023 - mdpi.com
A novel peptide, Cm39, was identified in the venom of the scorpion Centruroides
margaritatus. Its primary structure was determined. It consists of 37 amino acid residues with …
margaritatus. Its primary structure was determined. It consists of 37 amino acid residues with …
Whole Transcriptome of the Venom Gland from Urodacus yaschenkoi Scorpion
Australian scorpion venoms have been poorly studied, probably because they do not pose
an evident threat to humans. In addition, the continent has other medically important …
an evident threat to humans. In addition, the continent has other medically important …
KV1. 2 channel-specific blocker from Mesobuthus eupeus scorpion venom: Structural basis of selectivity
AI Kuzmenkov, OV Nekrasova, S Peigneur… - …, 2018 - Elsevier
Scorpion venom is an unmatched source of selective high-affinity ligands of potassium
channels. There is a high demand for such compounds to identify and manipulate the …
channels. There is a high demand for such compounds to identify and manipulate the …
Scorpion toxins targeting Kv1. 3 channels: insights into immunosuppression
Scorpion venoms are natural sources of molecules that have, in addition to their toxic
function, potential therapeutic applications. In this source the neurotoxins can be found …
function, potential therapeutic applications. In this source the neurotoxins can be found …
Transcriptomic analysis of the venom glands from the scorpion Hadogenes troglodytes revealed unique and extremely high diversity of the venom peptides
J Zhong, XC Zeng, X Zeng, Y Nie, L Zhang, S Wu… - Journal of …, 2017 - Elsevier
Hadogenes is a genus of large African scorpions with 18 described species. However, little
is known about the venom peptide composition of any species from Hadogenes so far. Here …
is known about the venom peptide composition of any species from Hadogenes so far. Here …
Orally Delivered Scorpion Antimicrobial Peptides Exhibit Activity against Pea Aphid (Acyrthosiphon pisum) and Its Bacterial Symbionts
K Luna-Ramirez, M Skaljac, J Grotmann, P Kirfel… - Toxins, 2017 - mdpi.com
Aphids are severe agricultural pests that damage crops by feeding on phloem sap and
vectoring plant pathogens. Chemical insecticides provide an important aphid control …
vectoring plant pathogens. Chemical insecticides provide an important aphid control …
Arthropod toxins acting on neuronal potassium channels
Arthropod venoms are a rich mixture of biologically active compounds exerting different
physiological actions across diverse phyla and affecting multiple organ systems including …
physiological actions across diverse phyla and affecting multiple organ systems including …
[HTML][HTML] New High-Affinity Peptide Ligands for Kv1. 2 Channel: Selective Blockers and Fluorescent Probes
AA Ignatova, EV Kryukova, VN Novoseletsky… - Cells, 2024 - mdpi.com
Advanced molecular probes are required to study the functional activity of the Kv1. 2
potassium channel in normal and pathological conditions. To address this, a fully active Kv1 …
potassium channel in normal and pathological conditions. To address this, a fully active Kv1 …