A strong connection exists between the cell cycle and mechanisms required for executing
cell fate decisions in a wide-range of developmental contexts. Terminal differentiation is …

Since the earliest observations of cells undergoing mitosis, it has been clear that there is an
intimate relationship between the cell cycle and nuclear chromatin architecture. The nuclear …

Despite the widespread interest in direct neuronal reprogramming, the mechanisms
underpinning fate conversion remain largely unknown. Our study revealed a critical time …

Cell-type-specific 3D organization of the genome is unrecognizable during mitosis. It
remains unclear how essential positional information is transmitted through cell division …

Mitotic bookmarking transcription factors remain bound to chromosomes during mitosis and
were proposed to regulate phenotypic maintenance of stem and progenitor cells at the …

During mitosis, transcription is halted and many chromatin features are lost, posing a
challenge for the continuity of cell identity, particularly in fast cycling stem cells, which …

The key signalling pathways and transcriptional programmes that instruct neuronal diversity
during development have largely been identified. In this Review, we discuss how this …

Metazoan development requires the robust proliferation of progenitor cells, the identities of
which are established by tightly controlled transcriptional networks. As gene expression is …

H3K9 methylation maintains cell identity orchestrating stable silencing and anchoring of
alternate fate genes within the heterochromatic compartment underneath the nuclear lamina …

During mitosis, RNA polymerase II (Pol II) and many transcription factors dissociate from
chromatin, and transcription ceases globally. Transcription is known to restart in bulk by …