Matrix metalloproteinases in normal pregnancy and preeclampsia

J Chen, RA Khalil - Progress in molecular biology and translational …, 2017 - Elsevier
Normal pregnancy is associated with marked hemodynamic and uterine changes that allow
adequate uteroplacental blood flow and uterine expansion for the growing fetus. These …

Placental and renal pathways underlying pre-eclampsia

PE Andronikidi, E Orovou, E Mavrigiannaki… - International Journal of …, 2024 - mdpi.com
Pre-eclampsia is a serious complication of pregnancy characterized by a state of multiorgan
hypertensive disorders, with or without proteinuria and possible multiorgan dysfunction …

Mechanisms of endothelial dysfunction in hypertensive pregnancy and preeclampsia

JS Possomato-Vieira, RA Khalil - Advances in pharmacology, 2016 - Elsevier
Preeclampsia is a pregnancy-related disorder characterized by hypertension and could lead
to maternal and fetal morbidity and mortality. Although the causative factors and …

Restoring placental growth factor-soluble fms-like tyrosine kinase-1 balance reverses vascular hyper-reactivity and hypertension in pregnancy

M Zhu, Z Ren, JS Possomato-Vieira… - American Journal of …, 2016 - journals.physiology.org
Preeclampsia (PE) is a pregnancy-related hypertensive disorder (HTN-Preg) with unclear
mechanism. An imbalance between antiangiogenic soluble fms-like tyrosine kinase-1 (sFlt …

Placental growth factor reverses decreased vascular and uteroplacental MMP-2 and MMP-9 and increased MMP-1 and MMP-7 and collagen types I and IV in …

Z Ren, N Cui, M Zhu, RA Khalil - American Journal of …, 2018 - journals.physiology.org
Preeclampsia is a complication of pregnancy manifested as maternal hypertension (HTN)
and fetal intrauterine growth restriction, with unclear mechanisms. Placental ischemia …

Choroidal and retinal thickening in severe preeclampsia

A Garg, RJ Wapner, CV Ananth, E Dale… - … & Visual Science, 2014 - iovs.arvojournals.org
Purpose.: To compare choroidal thickness and retinal macular volume (RMV) among three
groups of women: severe preeclampsia postpartum, normotensive postpartum, and …

MicroRNAs targeting VEGF are related to vascular dysfunction in preeclampsia

I Witvrouwen, D Mannaerts, J Ratajczak… - Bioscience …, 2021 - portlandpress.com
Abstract In preeclampsia (PE), pre-existent maternal endothelial dysfunction leads to
impaired placentation and vascular maladaptation. The vascular endothelial growth factor …

New views on endothelial dysfunction in gestational hypertension and potential therapy targets

X Feng, Y Liu, Y Zhang, Y Zhang, H Li, Q Zheng, N Li… - Drug discovery today, 2021 - Elsevier
Highlights•Reviewing major theories on pregnant hypertension & focusing on endothelial
dysfunction.•Endothelial NO is weak & exogenous NO makes “big dent” on placental vessel …

[HTML][HTML] Ophthalmic pathology of preeclampsia

EM Stern, N Blace - StatPearls [Internet], 2024 - ncbi.nlm.nih.gov
Objectives: Describe the signs and symptoms of visual pathology in preeclampsia.
Summarize what is known about visual changes in preeclampsia. Review specific etiologies …

Molecular determinants of microvascular dysfunction in hypertensive pregnancy and preeclampsia

W Yu, W Gao, D Rong, Z Wu, RA Khalil - Microcirculation, 2019 - Wiley Online Library
Preeclampsia is a pregnancy‐related disorder characterized by hypertension and often fetal
intrauterine growth restriction, but the underlying mechanisms are unclear. Defective …