Ubiquitin–proteasome system (UPS) as a target for anticancer treatment
J Park, J Cho, EJ Song - Archives of pharmacal research, 2020 - Springer
The ubiquitin–proteasome system (UPS) plays an important role in the cellular processes for
protein quality control and homeostasis. Dysregulation of the UPS has been implicated in …
protein quality control and homeostasis. Dysregulation of the UPS has been implicated in …
Functions and mechanisms of non-histone protein acetylation
N ε-lysine acetylation was discovered more than half a century ago as a post-translational
modification of histones and has been extensively studied in the context of transcription …
modification of histones and has been extensively studied in the context of transcription …
Molecular basis of USP7 inhibition by selective small-molecule inhibitors
AP Turnbull, S Ioannidis, WW Krajewski… - Nature, 2017 - nature.com
Ubiquitination controls the stability of most cellular proteins, and its deregulation contributes
to human diseases including cancer. Deubiquitinases remove ubiquitin from proteins, and …
to human diseases including cancer. Deubiquitinases remove ubiquitin from proteins, and …
DNA methylation: roles in mammalian development
ZD Smith, A Meissner - Nature Reviews Genetics, 2013 - nature.com
DNA methylation is among the best studied epigenetic modifications and is essential to
mammalian development. Although the methylation status of most CpG dinucleotides in the …
mammalian development. Although the methylation status of most CpG dinucleotides in the …
Epigenetic inheritance and the missing heritability
Genome-wide association studies of complex physiological traits and diseases consistently
found that associated genetic factors, such as allelic polymorphisms or DNA mutations, only …
found that associated genetic factors, such as allelic polymorphisms or DNA mutations, only …
Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer
Cancer cells often require glutamine for growth, thereby distinguishing them from most
normal cells. Here we show that PIK3CA mutations reprogram glutamine metabolism by …
normal cells. Here we show that PIK3CA mutations reprogram glutamine metabolism by …
Staying true to yourself: mechanisms of DNA methylation maintenance in mammals
DNA methylation is essential to development and cellular physiology in mammals. Faulty
DNA methylation is frequently observed in human diseases like cancer and neurological …
DNA methylation is frequently observed in human diseases like cancer and neurological …
Analysis of human acetylation stoichiometry defines mechanistic constraints on protein regulation
Lysine acetylation is a reversible posttranslational modification that occurs at thousands of
sites on human proteins. However, the stoichiometry of acetylation remains poorly …
sites on human proteins. However, the stoichiometry of acetylation remains poorly …
DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination
W Qin, P Wolf, N Liu, S Link, M Smets, FL Mastra… - Cell research, 2015 - nature.com
DNMT1 is recruited by PCNA and UHRF1 to maintain DNA methylation after replication.
UHRF1 recognizes hemimethylated DNA substrates via the SRA domain, but also …
UHRF1 recognizes hemimethylated DNA substrates via the SRA domain, but also …
Allosteric control of mammalian DNA methyltransferases–a new regulatory paradigm
In mammals, DNA methylation is introduced by the DNMT1, DNMT3A and DNMT3B
methyltransferases, which are all large multi-domain proteins containing a catalytic C …
methyltransferases, which are all large multi-domain proteins containing a catalytic C …