Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy

S Ma, MA Caligiuri, J Yu - Trends in immunology, 2022 - cell.com
Natural killer (NK) cells, a crucial component of the innate immune system, have long been
of clinical interest for their antitumor properties. Almost every aspect of NK cell immunity is …

[HTML][HTML] Concepts in Boolean network modeling: What do they all mean?

JD Schwab, SD Kühlwein, N Ikonomi, M Kühl… - Computational and …, 2020 - Elsevier
Boolean network models are one of the simplest models to study complex dynamic behavior
in biological systems. They can be applied to unravel the mechanisms regulating the …

Somatic STAT3 Mutations in Large Granular Lymphocytic Leukemia

HLM Koskela, S Eldfors, P Ellonen… - New England journal …, 2012 - Mass Medical Soc
Background T-cell large granular lymphocytic leukemia is a rare lymphoproliferative
disorder characterized by the expansion of clonal CD3+ CD8+ cytotoxic T lymphocytes …

Boolean modeling in systems biology: an overview of methodology and applications

RS Wang, A Saadatpour, R Albert - Physical biology, 2012 - iopscience.iop.org
Mathematical modeling of biological processes provides deep insights into complex cellular
systems. While quantitative and continuous models such as differential equations have been …

LGL leukemia: from pathogenesis to treatment

T Lamy, A Moignet… - Blood, The Journal of the …, 2017 - ashpublications.org
Large granular lymphocyte (LGL) leukemia has been recognized by the World Health
Organization classifications amongst mature T-cell and natural killer (NK) cell neoplasms …

Toward stabilizable large-scale Boolean networks by controlling the minimal set of nodes

S Zhu, J Cao, L Lin, J Lam… - IEEE Transactions on …, 2023 - ieeexplore.ieee.org
This article studies structural controllers and distributed pinning controllers for the global
stabilization of Boolean networks (BNs) by integrating the information on their network …

Realistic control of network dynamics

SP Cornelius, WL Kath, AE Motter - Nature communications, 2013 - nature.com
The control of complex networks is of paramount importance in areas as diverse as
ecosystem management, emergency response and cell reprogramming. A fundamental …

Logical modeling and dynamical analysis of cellular networks

W Abou-Jaoudé, P Traynard, PT Monteiro… - Frontiers in …, 2016 - frontiersin.org
The logical (or logic) formalism is increasingly used to model regulatory and signaling
networks. Complementing these applications, several groups contributed various methods …

Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia

HLM Rajala, S Eldfors, H Kuusanmäki… - Blood, The Journal …, 2013 - ashpublications.org
Large granular lymphocytic (LGL) leukemia is characterized by clonal expansion of cytotoxic
T cells or natural killer cells. Recently, somatic mutations in the signal transducer and …

Reconciling qualitative, abstract, and scalable modeling of biological networks

L Paulevé, J Kolčák, T Chatain, S Haar - Nature communications, 2020 - nature.com
Predicting biological systems' behaviors requires taking into account many molecular and
genetic elements for which limited information is available past a global knowledge of their …