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Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy
Natural killer (NK) cells, a crucial component of the innate immune system, have long been
of clinical interest for their antitumor properties. Almost every aspect of NK cell immunity is …
of clinical interest for their antitumor properties. Almost every aspect of NK cell immunity is …
[HTML][HTML] Concepts in Boolean network modeling: What do they all mean?
Boolean network models are one of the simplest models to study complex dynamic behavior
in biological systems. They can be applied to unravel the mechanisms regulating the …
in biological systems. They can be applied to unravel the mechanisms regulating the …
Somatic STAT3 Mutations in Large Granular Lymphocytic Leukemia
HLM Koskela, S Eldfors, P Ellonen… - New England journal …, 2012 - Mass Medical Soc
Background T-cell large granular lymphocytic leukemia is a rare lymphoproliferative
disorder characterized by the expansion of clonal CD3+ CD8+ cytotoxic T lymphocytes …
disorder characterized by the expansion of clonal CD3+ CD8+ cytotoxic T lymphocytes …
Boolean modeling in systems biology: an overview of methodology and applications
Mathematical modeling of biological processes provides deep insights into complex cellular
systems. While quantitative and continuous models such as differential equations have been …
systems. While quantitative and continuous models such as differential equations have been …
LGL leukemia: from pathogenesis to treatment
T Lamy, A Moignet… - Blood, The Journal of the …, 2017 - ashpublications.org
Large granular lymphocyte (LGL) leukemia has been recognized by the World Health
Organization classifications amongst mature T-cell and natural killer (NK) cell neoplasms …
Organization classifications amongst mature T-cell and natural killer (NK) cell neoplasms …
Toward stabilizable large-scale Boolean networks by controlling the minimal set of nodes
This article studies structural controllers and distributed pinning controllers for the global
stabilization of Boolean networks (BNs) by integrating the information on their network …
stabilization of Boolean networks (BNs) by integrating the information on their network …
Realistic control of network dynamics
The control of complex networks is of paramount importance in areas as diverse as
ecosystem management, emergency response and cell reprogramming. A fundamental …
ecosystem management, emergency response and cell reprogramming. A fundamental …
Logical modeling and dynamical analysis of cellular networks
W Abou-Jaoudé, P Traynard, PT Monteiro… - Frontiers in …, 2016 - frontiersin.org
The logical (or logic) formalism is increasingly used to model regulatory and signaling
networks. Complementing these applications, several groups contributed various methods …
networks. Complementing these applications, several groups contributed various methods …
Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia
HLM Rajala, S Eldfors, H Kuusanmäki… - Blood, The Journal …, 2013 - ashpublications.org
Large granular lymphocytic (LGL) leukemia is characterized by clonal expansion of cytotoxic
T cells or natural killer cells. Recently, somatic mutations in the signal transducer and …
T cells or natural killer cells. Recently, somatic mutations in the signal transducer and …
Reconciling qualitative, abstract, and scalable modeling of biological networks
Predicting biological systems' behaviors requires taking into account many molecular and
genetic elements for which limited information is available past a global knowledge of their …
genetic elements for which limited information is available past a global knowledge of their …