Latest developments in coumarin-based anticancer agents: mechanism of action and structure–activity relationship studies
Many researchers around the world are working on the development of novel anticancer
drugs with different mechanisms of action. In this case, coumarin is a highly promising …
drugs with different mechanisms of action. In this case, coumarin is a highly promising …
Green synthesis of hydrazono-thiazolones using vitamin B1 and their antibacterial implications
The study focuses on green methodologies in synthetic organic chemistry, emphasizing the
use of thiamine hydrochloride (Vitamin B1) as an eco-friendly catalyst for synthesizing …
use of thiamine hydrochloride (Vitamin B1) as an eco-friendly catalyst for synthesizing …
Mechanochemical synthesis and molecular docking studies of new azines bearing indole as anticancer agents
MS Ibrahim, B Farag, J Y. Al-Humaidi, MEA Zaki… - Molecules, 2023 - mdpi.com
The development of new approaches for the synthesis of new bioactive heterocyclic
derivatives is of the utmost importance for pharmaceutical industry. In this regard, the …
derivatives is of the utmost importance for pharmaceutical industry. In this regard, the …
A green synthesis, DFT calculations, and molecular docking study of some new indeno [2, 1-b] quinoxalines containing thiazole moiety
AM Abdallah, SM Gomha, MEA Zaki… - Journal of Molecular …, 2023 - Elsevier
A series of new indenoquinoxaline-thiazole hybrids were synthesized by combining
indenoquinoxaline thiosemicarbazone with appropriate hydrazonoyl chlorides or α-halo …
indenoquinoxaline thiosemicarbazone with appropriate hydrazonoyl chlorides or α-halo …
[HTML][HTML] Synthesis, in-silico studies, and biological evaluation of some novel 3-thiazolyl-indoles as CDK2–inhibitors
SM Gomha, MEA Zaki, D Maliwal, RRS Pissurlenkar… - Results in …, 2023 - Elsevier
The essential enzyme cyclin-dependent kinase 2 (CDK2) is a promising target for anticancer
drug development due to its pivotal role in regulating the cell cycle. This study aimed to …
drug development due to its pivotal role in regulating the cell cycle. This study aimed to …
[HTML][HTML] Efficient green synthesis of hydrazide derivatives using L-proline: Structural characterization, anticancer activity, and molecular docking studies
Green synthesis using L-proline as an organocatalyst is crucial due to its reusability, mild
conditions, clean reactions, easy workup, high purity, short reaction times, and high yields …
conditions, clean reactions, easy workup, high purity, short reaction times, and high yields …
[HTML][HTML] Synthesis, molecular docking study, and biological evaluation and of new thiadiazole and thiazole derivatives incorporating isoindoline-1, 3-dione moiety as …
To highlight the importance of thiazole and thiadiazole derivatives in the progression of
cancer and microbial treatments and to aid in drug design, we have synthesized a new …
cancer and microbial treatments and to aid in drug design, we have synthesized a new …
Synthesis of novel 6-aminocoumarin derivatives as potential–biocompatible antimicrobial and anticancer agents
YF Mustafa - Journal of Molecular Structure, 2025 - Elsevier
Among the most health-influencing threats, microbial infections and cancer have attracted a
mounting interest in the medical field. To face these threats, research is directed to improve …
mounting interest in the medical field. To face these threats, research is directed to improve …
Chitosan–sulfonic acid-catalyzed green synthesis of naphthalene-based azines as potential anticancer agents
AYA Alzahrani, SM Gomha, MEA Zaki… - Future Medicinal …, 2024 - Taylor & Francis
Aim: This study focuses on advancing green chemistry in anticancer drug discovery,
particularly through the synthesis of azine derivatives with a naphthalene core using CS …
particularly through the synthesis of azine derivatives with a naphthalene core using CS …
New Thiazolyl-Pyrazoline derivatives as potential dual EGFR/HER2 inhibitors: design, synthesis, anticancer activity evaluation and in silico study
A new series of thiazolyl-pyrazoline derivatives (4a–d, 5a–d 6a, b, 7a–d, 8a, b, and 10a, b)
have been designed and synthesized through the combination of thiazole and pyrazoline …
have been designed and synthesized through the combination of thiazole and pyrazoline …